TITANIUM DETERMINATION AS A METHOD OF QUANTIFYING FILM-COAT APPLICATION ON TO TABLETS

被引：6

作者：

HARRISON, JJ

LAFFERTY, I

MOORE, WD

RAWLINS, DA

RISSEN, NR

THWAITES, PM

机构：

[1] Development Laboratories, Merck Sharp and Dohme, Hoddesdon, England

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1991年 / 17卷 / 01期

关键词：

D O I：

10.3109/03639049109043815

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A method for assessing the extent and uniformity of film-coat application on to tablets by the determination of titanium is reported. The method is utilised to determine the ideal charge of tablets in a 24" Accela-Cota for the application of a water insoluble film-coat which is intended to be rate controlling. The results are compared with those obtained using conventional methods of process optimisation ie dissolution testing.

引用

页码：149 / 155

页数：7