PHOTOSENSITIZATION CAUSED BY IBUPROFEN

被引：16

作者：

BERGNER, T ^{[1
]}

PRZYBILLA, B ^{[1
]}

机构：

[1] UNIV MUNICH,DERMATOL KLIN & POLIKLIN,W-8000 MUNICH 2,GERMANY

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1992年 / 26卷 / 01期

关键词：

D O I：

10.1016/0190-9622(92)70018-B

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Several nonsteroid antiinflammatory drugs (eg., benoxaprofen, carprofen, and piroxicam) are known to induce photosensitivity reactions, but this has not yet been documented for ibuprofen. We observed a photosensitivity reaction in a patient treated with an oral ibuprofen preparation. This patient had a lowered minimal erythema dose for UVA but not for UVB after oral administration of ibuprofen. Results of a photopatch test with the drug were negative. In vitro UVA irradiation of human erythrocytes in the presence of ibuprofen caused ultraviolet dose-dependent phototoxic hemolysis.

引用

页码：114 / 116

页数：3

共 14 条

[1] PHARMACOKINETICS OF IBUPROFEN [J].

ALBERT, KS ;

GERNAAT, CM .

AMERICAN JOURNAL OF MEDICINE, 1984, 77 (1A) :40-46

[2]

BAILIN PL, 1982, CLIN RHEUM DIS, V8, P493

[3] CUTANEOUS REACTIONS TO NONSTEROIDAL ANTI-INFLAMMATORY DRUGS - A REVIEW [J].

BIGBY, M ;

STERN, R .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1985, 12 (05) :866-876

[4] CURRENT STATUS OF MAMMALIAN AND HUMAN MODELS FOR PREDICTING DRUG PHOTOSENSITIVITY [J].

HARBER, LC .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1981, 77 (01) :65-70

[5] PHOTOSENSITIZING POTENTIAL OF CERTAIN NONSTEROIDAL ANTI-INFLAMMATORY AGENTS [J].

KAIDBEY, KH ;

MITCHELL, FN .

ARCHIVES OF DERMATOLOGY, 1989, 125 (06) :783-786

[6] IBUPROFEN [J].

KANTOR, TG .

ANNALS OF INTERNAL MEDICINE, 1979, 91 (06) :877-882

[7] PHOTOTOXICITY OF NONSTEROIDAL INFLAMMATORY DRUGS - COINCIDENCE OR SPECIFIC MECHANISM [J].

KOCHEVAR, IE .

ARCHIVES OF DERMATOLOGY, 1989, 125 (06) :824-826

[8]

LJUNGGREN B, 1985, PHOTODERMATOLOGY, V2, P3

[9]

LJUNGGREN B, 1985, PHOTODERMATOLOGY, V2, P377

[10] DEMONSTRATION OF QUINOLONE PHOTOTOXICITY INVITRO [J].

PRZYBILLA, B ;

GEORGII, A ;

BERGNER, T ;

RING, J .

DERMATOLOGICA, 1990, 181 (02) :98-103

← 1 2 →