CALCIUM-CHANNEL BLOCKING-AGENTS AND POTASSIUM-STIMULATED RELEASE OF GLUTAMATE FROM CEREBELLAR SLICES

被引：27

作者：

DICKIE, BGM ^{[1
]}

DAVIES, JA ^{[1
]}

机构：

[1] UNIV WALES COLL MED,DEPT PHARMACOL & THERAPEUT,HEATH PK,CARDIFF CF4 4XN,S GLAM,WALES

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 229卷 / 01期

关键词：

CA2+ CHANNEL BLOCKERS; GLUTAMATE; CEREBELLAR SLICES;

D O I：

10.1016/0014-2999(92)90291-B

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of calcium channel blockers and tetrodotoxin on the potassium-stimulated release of endogenous glutamate from rat cerebellar slices was assessed. Verapamil (10 muM), omega-conotoxin (1 and 10 muM) and cobalt (2 mM) all significantly decreased release. Amiloride (100 muM) and tetrodotoxin (0.5 and 1 muM) had no effect. The results suggest a role for N-type voltage-operated calcium channels in the potassium-stimulated release of glutamate.

引用

页码：97 / 99

页数：3

共 10 条

[1] THE EFFECTS OF CALCIUM-CHANNEL AGONISTS AND ANTAGONISTS ON THE RELEASE OF ENDOGENOUS GLUTAMATE FROM CEREBELLAR SLICES [J].

BARNES, S ;

DAVIES, JA .

NEUROSCIENCE LETTERS, 1988, 92 (01) :58-63

[2] A NOVEL SUPERFUSION CHAMBER FOR THE MEASUREMENT OF ENDOGENOUS GLUTAMATE RELEASE FROM CEREBELLAR SLICES [J].

BARNES, S ;

LEIGHTON, GE ;

DAVIES, JA .

JOURNAL OF NEUROSCIENCE METHODS, 1988, 23 (01) :57-61

[3] INVITRO RELEASE OF ENDOGENOUS AMINO-ACIDS FROM GRANULE CELL-DEFICIENT, STELLATE CELL-DEFICIENT, AND CLIMBING FIBER-DEFICIENT CEREBELLA [J].

FLINT, RS ;

REA, MA ;

MCBRIDE, WJ .

JOURNAL OF NEUROCHEMISTRY, 1981, 37 (06) :1425-1430

[4] CALCIUM CHANNELS IN VERTEBRATE CELLS [J].

HESS, P .

ANNUAL REVIEW OF NEUROSCIENCE, 1990, 13 :337-356

[5] INHIBITION OF K+-EVOKED [H-3] D-ASPARTATE RELEASE AND NEURONAL CALCIUM INFLUX BY VERAPAMIL, DILTIAZEM AND DEXTROMETHORPHAN - EVIDENCE FOR NON-L NON-N VOLTAGE-SENSITIVE CALCIUM CHANNELS [J].

MANGANO, TJ ;

PATEL, J ;

SALAMA, AI ;

KEITH, RA .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 192 (01) :9-17

[6] RELATIONSHIP OF DIHYDROPYRIDINE BINDING-SITES WITH CALCIUM-DEPENDENT NEUROTRANSMITTER RELEASE IN SYNAPTOSOMES [J].

MASSIEU, L ;

TAPIA, R .

JOURNAL OF NEUROCHEMISTRY, 1988, 51 (04) :1184-1189

[7] OMEGA-CONOTOXIN - DIRECT AND PERSISTENT BLOCKADE OF SPECIFIC TYPES OF CALCIUM CHANNELS IN NEURONS BUT NOT MUSCLE [J].

MCCLESKEY, EW ;

FOX, AP ;

FELDMAN, DH ;

CRUZ, LJ ;

OLIVERA, BM ;

TSIEN, RW ;

YOSHIKAMI, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (12) :4327-4331

[8] MULTIPLE CALCIUM CHANNELS MEDIATE NEUROTRANSMITTER RELEASE FROM PERIPHERAL NEURONS [J].

PERNEY, TM ;

HIRNING, LD ;

LEEMAN, SE ;

MILLER, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (17) :6656-6659

[9] AMILORIDE SELECTIVELY BLOCKS THE LOW THRESHOLD (T) CALCIUM-CHANNEL [J].

TANG, CM ;

PRESSER, F ;

MORAD, M .

SCIENCE, 1988, 240 (4849) :213-215

[10] REPETITIVE ACTION-POTENTIALS IN ISOLATED NERVE-TERMINALS IN THE PRESENCE OF 4-AMINOPYRIDINE - EFFECTS ON CYTOSOLIC FREE CA-2+ AND GLUTAMATE RELEASE [J].

TIBBS, GR ;

BARRIE, AP ;

VANMIEGHEM, FJE ;

MCMAHON, HT ;

NICHOLLS, DG .

JOURNAL OF NEUROCHEMISTRY, 1989, 53 (06) :1693-1699

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