REDUCED MEASLES IMMUNITY IN INFANTS IN A WELL-VACCINATED POPULATION

被引:80
作者
PABST, HF
SPADY, DW
MARUSYK, RG
CARSON, MM
CHUI, LWL
JOFFRES, MR
GRIMSRUD, KM
机构
[1] UNIV ALBERTA,DEPT MICROBIOL & INFECT DIS,EDMONTON T6G 2R7,ALBERTA,CANADA
[2] EDMONTON BOARD HLTH,EDMONTON,ALBERTA,CANADA
关键词
MEASLES IMMUNITY; INFANTS; MATERNAL IMMUNITY; VACCINATED MOTHERS;
D O I
10.1097/00006454-199207000-00004
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The recommended age for measles vaccination is based in part on information gathered when most mothers had natural measles. Nowadays many mothers have received measles vaccine. To assess this change measles antibody neutralization titers (NT) were determined for 278 mother-infant pairs. One hundred sixty-four mothers, born before 1958, likely had had natural measles (Group 1). Sixty mothers received one to three killed plus one attenuated measles vaccination (Group 2) and 54 received 1 attenuated measles vaccination only (Group 3). NT were determined for the mother and for the infant at birth and in the infant during the fourth and sixth months. Group 1 mothers and infants at every age had higher geometric mean NT than those in Groups 2 or 3 (P < 0.05). By 7 months 65% of Group 1 infants and >90% of Group 2 and 3 infants had an NT < 1: 10. The rate of antibody decay was significantly faster for Group 1 infants (P < 0.05). Earlier vaccination in the infant should be considered.
引用
收藏
页码:525 / 529
页数:5
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