CONSERVED MECHANISM OF NEGATIVE GENE-REGULATION BY EXTRACELLULAR CALCIUM - PARATHYROID-HORMONE GENE VERSUS ATRIAL NATRIURETIC POLYPEPTIDE GENE

被引：40

作者：

OKAZAKI, T

ANDO, K

IGARASHI, T

OGATA, E

FUJITA, T

机构：

[1] 4th Department of Internal Medicine, University of Tokyo, School of Medicine

[2] Department of Internal Medicine, University of Tokyo, School of Medicine, Bunkyo-ku, Tokyo 112, 3-28-6, Mejirodai

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1992年 / 89卷 / 04期

关键词：

NEGATIVE CALCIUM-RESPONSIVE ELEMENT; INVIVO INFUSION SYSTEM; TRANSFECTION; GENE FAMILY; NUCLEAR PROTEIN;

D O I：

10.1172/JCI115711

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We found that a negative calcium-responsive element (nCaRE) originally reported in the human parathyroid hormone gene is conserved among several genes. The results of the present study show that expression of one of the genes, the rat atrial natriuretic polypeptide gene, was negatively regulated in the heart by extracellular calcium by using an in vivo infusion system. Moreover, transfection of the cultured cells revealed that this DNA element conferred negative regulation by extracellular calcium on the reporter gene. It is suggested that there is a gene family whose expression is negatively regulated by extracellular calcium through this conserved DNA motif, nCaRE.

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页码：1268 / 1273

页数：6

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