SHORT-STEP SYNTHESIS OF CHIRAL C2-SYMMETRICAL 2,3,4,5-TETRASUBSTITUTED PYRROLIDINES FROM D-MANNITOL AND THEIR USE AS CHIRAL LIGANDS IN THE REACTION OF DIETHYLZINC AND BENZALDEHYDE

被引：43

作者：

MASAKI, Y

ODA, H

KAZUTA, K

USUI, A

ITOH, A

XU, F

机构：

[1] Gifu Pharmaceutical University, Gifu, 502

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 35期

关键词：

D O I：

10.1016/S0040-4039(00)61197-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(3R,4R)-Bis(hydroxy)-(2S,5S)-bis(hydroxymethyl)-pyrrolidine and related chiral C2-symmetric pyrrolidines including D2-symmetric 1,2-bis(1-pyrrolidino)-ethanes and N-hydroxyethylpyrrolidines were synthesized highly practically from D-mannitol and a high chiral induction of 82% ee was observed in investigation of efficiency of these amines as chiral catalyst ligands in the addition reaction of diethylzinc to benzaldehyde.

引用

页码：5089 / 5092

页数：4

共 32 条

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