FAILURE OF SISTER-CHROMATID SEPARATION LEADS TO FORMATION OF DIPLOCHROMOSOMES IN COLCEMID TREATED PTK1 CELLS

被引：2

作者：

GHOSH, S

PAWELETZ, N

SCHROETER, D

机构：

[1] GERMAN CANC RES CTR,DIV 0430,RES PROGRAM 4,NEUENHEIMER FELD 280,D-69120 HEIDELBERG,GERMANY

[2] UNIV CALCUTTA,DEPT BOT,CALCUTTA 700019,W BENGAL,INDIA

来源：

CELL BIOLOGY INTERNATIONAL | 1993年 / 17卷 / 10期

关键词：

D O I：

10.1006/cbir.1993.1017

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The origin of diplochromosomes has been traced in multinucleate rat kangaroo cells (PtK1) obtained after colcemid treatment. In these cells the diplochromosomes were shown to originate from restitution nuclei, indicating that they were formed due to the omission or failure of sister chromatid separation and not due to endoreduplication. In this context the mechanism of sister chromatid separation has been discussed. The independence of this mitotic event from other associated processes, such as chromosome condensation, nuclear envelope breakdown or spindle formation has been stressed. © 1993 Academic Press. All rights reserved.

引用

页码：945 / 948

页数：4

共 21 条

[1] SEQUENCE OF CENTROMERE SEPARATION - CHARACTERIZATION OF MULTICENTRIC CHROMOSOMES IN A RAT-CELL LINE [J].