CHANGES IN THE PRODUCTIVITY OF CYTOKINES AND ACTIVE-OXYGEN IN PERIPHERAL-BLOOD CELLS FOLLOWING SURGERY

被引：8

作者：

ABE, Y

MIYAKE, M

HORIUCHI, A

KUMORI, K

KIMURA, S

机构：

[1] The Second Department of Surgery, Ehime University School of Medicine, Ehime, 791-02, Onsen-gun, Shigenobu-cho

来源：

SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY | 1992年 / 22卷 / 01期

关键词：

TNF; IL-1-ALPHA; LYMPHOTOXIN; INF-GAMMA; ACTIVE-OXYGEN; SURGICAL STRESS;

D O I：

10.1007/BF00326119

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

An investigation was carried out on the productivity of cytokines and active-oxygen by peripheral blood cells during the pre- and post-operative periods. While the preoperative production of tumor necrosis factor (TNF) and interleukin-1-alpha (IL-1-alpha) was elevated, that of lymphotoxin (LT) and interferon-gamma (IFN-gamma) were slightly suppressed. In the postoperative period the peak TNF and IL-1-alpha and active-oxygen productivity was elevated, while LT and IFN-gamma productivity was suppressed in patients with an intraoperative bleeding volume of more than 1,000 ml compared to those with that of less than 1,000 ml. Thus, stress stimulates the TNF and IL-1-alpha and active-oxygen producing system, that is, the macrophage-neutrophil system, and suppresses the LT and IFN-gamma system, being, the inflammatory helper T cell system, in the early postoperative period.

引用

页码：15 / 18

页数：4

共 18 条

[1] Wilmore D.W., Homeostasis: Bodily changes in trauma and surgery, Textbook of surgery, pp. 23-37, (1986)
[2] Abe Y., Miyake M., Sagawa T., Kimura S., Enzyme-linked immunosorbent assay (ELISA) for human tumor necrosis factor (hTNF), Clin Chim Acta, 176, pp. 213-218, (1988)
[3] Abe Y., Miyaka M., Miyazaki T., Horiuchi A., Sagawa T., Ono H., Kimura S., Nonspecific reaction in the sandwich immunoassay for human tumor necrosis factor-α (hTNF-α), Clin Chim Acta, 181, pp. 223-230, (1989)
[4] Abe Y., Miyaka M., Horiuchi A., Kimura S., Induction of cytokines by Polysaccharide K in the peripheral-blood mononuclear cell culture, Igakunoayumi, 152, pp. 617-618, (1990)
[5] Bass D.A., Parse J.W., Dechatelet L.R., Szejda P., Seed M.C., Thomas M., Flow cytometric studies of oxidative product formation by neutrophils. A graded response to membrane stimulation, J Immunol, 130, pp. 1910-1917, (1983)
[6] Taga K., Seki H., Taniguchi N., Flow cytometric evaluation of neutrophil functions on microquantities of whole blood, Clin Immunol, 17, pp. 490-498, (1985)
[7] Mayoral J.L., Schweich C.J., Dunn D.L., Decreased tumor necrosis factor production during the initial stages of infection correlates with survival during murine gram-negative sepsis, Arch Surg, 125, pp. 24-28, (1990)
[8] Cerami A., Beutler B., The role of cachectin/TNF in endotoxic shock and cachexia, Immunology Today, 9, pp. 28-31, (1988)
[9] Beutler B., Cerami A., The common mediator of shock, cachexia, and tumor necrosis, Adv in Immunol, 42, pp. 213-231, (1988)
[10] Mathison J.C., Wolfson E., Ulevitch R.J., Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits, J Clin Invest, 81, pp. 1925-1937, (1988)

← 1 2 →