V-JUN COOPERATES WITH V-ERBB TO TRANSFORM THE THROMBOCYTIC MEGAKARYOCYTIC LINEAGE

被引:8
作者
GARCIA, M
SAMARUT, J
机构
[1] Lab. Biologie Moleculaire/Cellulaire, CNRS, INRA, 69364 Lyon Cedex 07, 46, Allee d'Italie
关键词
TRANSCRIPTION FACTORS; HEMATOPOIESIS; TRANSFORMATION; MEGAKARYOPOIESIS;
D O I
10.1073/pnas.90.19.8837
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The transforming properties of v-jun, the viral counterpart of the transcription factor AP1, were investigated in avian hematopoietic cells. Two retroviruses, called JB and JBN, expressing both v-jun and v-erbB, were constructed using an avian erythroblastosis-based vector. We show that the cooperative action of both oncogenes allowed the virus to efficiently transform bone marrow cells. No such transformation was obtained with either oncogene alone. JB-transformed bone marrow cells expressed GATA-1, TAL-1, and histone H5, suggesting that they belong to the erythrocytic/thrombocytic lineage. (Thrombocytes are the avian homologues of mammal megakaryocytes.) Moreover, after induction with phorbol 12-myristate 13-acetate JB-transformed bone marrow cells began to differentiate and synthesized high levels of platelet glycoproteins, indicating that they were of thrombocytic origin. These results were confirmed by c-ets1 analysis since this transcription factor, specifically found in cells with megakaryocytic but not erythrocytic features, was clearly detected in these cells.
引用
收藏
页码:8837 / 8841
页数:5
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