NATURAL HIV-1 NEF ACCELERATES VIRUS-REPLICATION IN PRIMARY HUMAN-LYMPHOCYTES

被引：158

作者：

DERONDE, A

KLAVER, B

KEULEN, W

SMIT, L

GOUDSMIT, J

机构：

[1] Human Retrovirus Laboratory, University of Amsterdam, Academic Medical Centre, 1105 AZ Amsterdam

来源：

VIROLOGY | 1992年 / 188卷 / 01期

关键词：

D O I：

10.1016/0042-6822(92)90772-H

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

HIV-1 NEF genes were isolated directly from peripheral blood lymphocyte DNA of two HIV-1-infected individuals and cloned into an HXB-2-infectious molecular clone. The effect of NEF on virus production in T-cell lines and primary human lymphocytes was studied. Naturally occurring NEF accelerates virus production in primary human lymphocytes, but not in T-cell lines. © 1992.

引用

页码：391 / 395

页数：5

共 14 条

[1] NEF PROTEIN OF HIV-1 IS A TRANSCRIPTIONAL REPRESSOR OF HIV-1 LTR
AHMAD, N
VENKATESAN, S
[J]. SCIENCE, 1988, 241 (4872) : 1481 - 1485
[2] RAPID AND SIMPLE METHOD FOR PURIFICATION OF NUCLEIC-ACIDS
BOOM, R
SOL, CJA
SALIMANS, MMM
JANSEN, CL
WERTHEIMVANDILLEN, PME
VANDERNOORDAA, J
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1990, 28 (03) : 495 - 503
[3] DIFFERENTIAL-EFFECTS OF NEF ON HIV REPLICATION - IMPLICATIONS FOR VIRAL PATHOGENESIS IN THE HOST
CHENGMAYER, C
IANNELLO, P
SHAW, K
LUCIW, PA
LEVY, JA
[J]. SCIENCE, 1989, 246 (4937) : 1629 - 1632
[4] DEWOLF F, 1988, J INFECT DIS, V158, P615, DOI 10.1093/infdis/158.3.615
[5] NEF PROTEIN OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 - EVIDENCE AGAINST ITS ROLE AS A TRANSCRIPTIONAL INHIBITOR
HAMMES, SR
DIXON, EP
MALIM, MH
CULLEN, BR
GREENE, WC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (23) : 9549 - 9553
[6] SIV ADAPTION TO HUMAN-CELLS
HIRSCH, VM
EDMONDSON, P
MURPHEYCORB, M
ARBEILLE, B
JOHNSON, PR
MULLINS, JI
[J]. NATURE, 1989, 341 (6243) : 573 - 574
[7] IMPORTANCE OF THE NEF GENE FOR MAINTENANCE OF HIGH VIRUS LOADS AND FOR DEVELOPMENT OF AIDS
KESTLER, HW
RINGLER, DJ
MORI, K
PANICALI, DL
SEHGAL, PK
DANIEL, MD
DESROSIERS, RC
[J]. CELL, 1991, 65 (04) : 651 - 662
[8] LACK OF A NEGATIVE INFLUENCE ON VIRAL GROWTH BY THE NEF GENE OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1
KIM, SY
IKEUCHI, KJ
BYRN, R
GROOPMAN, J
BALTIMORE, D
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (23) : 9544 - 9548
[9] SIGNIFICANCE OF PREMATURE STOP CODONS IN ENV OF SIMIAN IMMUNODEFICIENCY VIRUS
KODAMA, T
WOOLEY, DP
NAIDU, YM
KESTLER, HW
DANIEL, MD
LI, Y
DESROSIERS, RC
[J]. JOURNAL OF VIROLOGY, 1989, 63 (11) : 4709 - 4714
[10] MUTATIONAL ANALYSIS OF THE HUMAN-IMMUNODEFICIENCY-VIRUS - THE ORF-B REGION DOWN-REGULATES VIRUS-REPLICATION
LUCIW, PA
CHENGMAYER, C
LEVY, JA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (05) : 1434 - 1438

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