INTRACELLULAR FREE [CA2+] AND [NA+] IN RESPONSE TO CAPSAICIN IN CULTURED DORSAL-ROOT GANGLION-CELLS

被引：13

作者：

AKERMAN, KEO ^{[1
]}

GRONBLAD, M ^{[1
]}

机构：

[1] UNIV HELSINKI,CENT HOSP,BACK PAIN RES UNIT,SF-00290 HELSINKI 29,FINLAND

来源：

NEUROSCIENCE LETTERS | 1992年 / 147卷 / 01期

关键词：

DORSAL ROOT GANGLION NEURON; CAPSAICIN; NA+; CA2+; FURA-2; SBFI;

D O I：

10.1016/0304-3940(92)90763-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intracellular free Ca2+ and Na+ concentrations in cultured rat dorsal root ganglion cells were studied using the intracellular fluorescent probes fura-2 and SBFI, respectively. Capsaicin increased both intracellular [Ca2+] and [Na+]. A rise in cytosolic free Ca2+ could still be seen if Na+ was removed from the outer medium. The results suggest that capsaicin opens up ion channels which are permeable both to Ca2+ and Na+.

引用

页码：13 / 15

页数：3

共 21 条

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