PROMOTER-SPECIFIC IMPRINTING OF THE HUMAN INSULIN-LIKE GROWTH FACTOR-II GENE

被引:209
作者
VU, TH [1 ]
HOFFMAN, AR [1 ]
机构
[1] STANFORD UNIV,DEPT MED,PALO ALTO,CA 94304
关键词
D O I
10.1038/371714a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
GENOMIC imprinting is a mechanism whereby only one of the two parental alleles is expressed. Loss or relaxation of genomic imprinting has been proposed as an epigenetic mechanism for oncogenesis in a variety of human tumours(1-6). Although the mechanism of imprinting is unknown, differential CpG methylation of the parental alleles has been implicated(7-12). The human insulinlike growth factor-II (IGF2) gene, which is transcribed from four promoters, P1-P4 (ref. 13), is imprinted in fetal liver(14,15) but biallelic expression occurs in adult liver(16). Like most tissues, fetal liver uses primarily promoters P3 and P4 (ref. 17). Adult liver, however, transcribes IGF2 from promoter P1, and it has been suggested that the recruitment of P1 may be responsible for the absence of imprinting in human liver, and in choroid plexus and leptomeninges(18). We report here that in liver and chondrocytes, IGF2 transcripts from promoter P1 are always derived from both parental alleles, whereas transcripts from promoters P2, P3 and P4 are always from one parental allele. These findings demonstrate that imprinting and a lack of imprinting can both occur within a single gene in a single tissue, suggesting that regional imprinting factors may be important.
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页码:714 / 717
页数:4
相关论文
共 24 条
  • [1] THE ONTOGENY OF ALLELE-SPECIFIC METHYLATION ASSOCIATED WITH IMPRINTED GENES IN THE MOUSE
    BRANDEIS, M
    KAFRI, T
    ARIEL, M
    CHAILLET, JR
    MCCARREY, J
    RAZIN, A
    CEDAR, H
    [J]. EMBO JOURNAL, 1993, 12 (09) : 3669 - 3677
  • [2] CATTANACH BM, 1990, DEVELOPMENT, P63
  • [3] PARENTAL-SPECIFIC METHYLATION OF AN IMPRINTED TRANSGENE IS ESTABLISHED DURING GAMETOGENESIS AND PROGRESSIVELY CHANGES DURING EMBRYOGENESIS
    CHAILLET, JR
    VOGT, TF
    BEIER, DR
    LEDER, P
    [J]. CELL, 1991, 66 (01) : 77 - 83
  • [4] PARENTAL IMPRINTING OF THE MOUSE INSULIN-LIKE GROWTH FACTOR-II GENE
    DECHIARA, TM
    ROBERTSON, EJ
    EFSTRATIADIS, A
    [J]. CELL, 1991, 64 (04) : 849 - 859
  • [5] EKSBERG R, 1993, NAT GENET, V5, P143
  • [6] GENOMIC IMPRINTING AND GENE ACTIVATION IN CANCER
    FEINBERG, AP
    [J]. NATURE GENETICS, 1993, 4 (02) : 110 - 113
  • [7] PARENTAL-ORIGIN-SPECIFIC EPIGENETIC MODIFICATION OF THE MOUSE H19 GENE
    FERGUSONSMITH, AC
    SASAKI, H
    CATTANACH, BM
    SURANI, MA
    [J]. NATURE, 1993, 362 (6422) : 751 - 755
  • [8] PARENTAL GENOMIC IMPRINTING OF THE HUMAN IGF2 GENE
    GIANNOUKAKIS, N
    DEAL, C
    PAQUETTE, J
    GOODYER, CG
    POLYCHRONAKOS, C
    [J]. NATURE GENETICS, 1993, 4 (01) : 98 - 101
  • [9] THE INSULIN-LIKE GROWTH-FACTOR TYPE-2 RECEPTOR GENE IS IMPRINTED IN THE MOUSE BUT NOT IN HUMANS
    KALSCHEUER, VM
    MARIMAN, EC
    SCHEPENS, MT
    REHDER, H
    ROPERS, HH
    [J]. NATURE GENETICS, 1993, 5 (01) : 74 - 78
  • [10] ROLE FOR DNA METHYLATION IN GENOMIC IMPRINTING
    LI, E
    BEARD, C
    JAENISCH, R
    [J]. NATURE, 1993, 366 (6453) : 362 - 365