APPLICATION OF INTRAMOLECULAR HECK REACTIONS FOR FORMING CONGESTED QUATERNARY CARBON CENTERS IN COMPLEX MOLECULE TOTAL SYNTHESIS

被引：149

作者：

OVERMAN, LE

机构：

[1] Department of Chemistry, University of California, Irvine

来源：

PURE AND APPLIED CHEMISTRY | 1994年 / 66卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1351/pac199466071423

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Palladium-catalyzed cyclizations of aryl halides, vinyl halides and vinyl triflates with tethered alkenes have proven to be powerful reactions for forging congested quaternary carbon centers in complex organic molecules. In some cases, the use of enantiopure ligands allows the new quaternary center to be formed with excellent enantioselectivity. The scope, stereochemical nuances and power of this organometallic chemistry is illustrated by briefly considering our recent total syntheses of (+/-)-pretazettine, (+/-)-tazettine, (-)- and (+)-morphine, (-)- and (+)-physostigmine, (+/-)-scopadulcic acid A and (+/-)-scopadulcic acid B.

引用

页码：1423 / 1430

页数：8

共 34 条

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