STEREOSPECIFIC SYNTHESIS OF CLOMIPHENE AND TAMOXIFEN VIA STANNYLCUPRATION OF DIPHENYLACETYLENE

被引：10

作者：

CUMMINS, CH

机构：

[1] Dow Chemical Company, Central Research and Development - Materials Research and Development Laboratory, Midland, MI 48674

来源：

SYNTHETIC COMMUNICATIONS | 1995年 / 25卷 / 24期

关键词：

D O I：

10.1080/00397919508011484

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stereospecific trans-stannylcupration of diphenylacetylene affords a 1,2-dimetallostilbene which may be elaborated into either Clomiphene or Tamoxifen through palladium-catalyzed coupling with an aryl iodide.

引用

页码：4071 / 4079

页数：9

共 16 条

[1] SYNTHESIS OF CLOMID USING PALLADIUM-CATALYZED CROSS-COUPLING [J].

ALHASSAN, MI .

SYNTHETIC COMMUNICATIONS, 1987, 17 (15) :1787-1796

[2]

ALHASSAN MI, 1987, SYNTHESIS-STUTTGART, P815

[3] SYNTHESIS OF CIS-TAMOXIFEN AND TRANS-TAMOXIFEN [J].

ALHASSAN, MI .

SYNTHETIC COMMUNICATIONS, 1987, 17 (10) :1247-1251

[4] A ONE-STEP SYNTHESIS OF CLOMID INTERMEDIATE [J].

ALHASSAN, MI .

ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 1991, 23 (01) :116-118

[5] SYNTHESIS, RECEPTOR-BINDING, AND TISSUE DISTRIBUTION OF 7-ALPHA-SUBSTITUTED AND 11-BETA-SUBSTITUTED (17-ALPHA,20E)-21-[I-125]IODO-19-NORPREGNA-1,3,5(10),20-TETRAENE-3,17-DIOLS AND (17-ALPHA,20Z)-21-[I-125]IODO-19-NORPREGNA-1,3,5(10),20-TETRAENE-3,17-DIOLS [J].

ALI, H ;

ROUSSEAU, J ;

GHAFFARI, MA ;

VANLIER, JE .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (02) :854-860

[6] CIS-TRANS STEREOSELECTIVITY IN THE STANNYLMETALLATION OF DIPHENYLACETYLENE [J].

CUMMINS, CH ;

GORDON, EJ .

TETRAHEDRON LETTERS, 1994, 35 (44) :8133-8136

[7] FORMATION OF CARBON-CARBON BOND ON SOLID SUPPORT - APPLICATION OF THE STILLE REACTION [J].

DESHPANDE, MS .

TETRAHEDRON LETTERS, 1994, 35 (31) :5613-5614

[8] STEREOCHEMISTRY OF GEOMETRIC ISOMERS OF CLOMIPHENE - CORRECTION OF LITERATURE AND A RE-EXAMINATION OF STRUCTURE-ACTIVITY-RELATIONSHIPS [J].

ERNST, S ;

HITE, G ;

CANTRELL, JS ;

RICHARDSON, A ;

BENSON, HD .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1976, 65 (01) :148-150

[9] CONTRASTING ENDOCRINE ACTIVITIES OF CIS AND TRANS ISOMERS IN A SERIES OF SUBSTITUTED TRIPHENYLETHYLENES [J].

HARPER, MJK ;

WALPOLE, AL .

NATURE, 1966, 212 (5057) :87-&

[10]

LEVY AB, 1977, TETRAHEDRON LETT, P3545

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