PARTICIPATION OF SUBSTANCE-P IN THE CONTROL OF RENIN RELEASE

被引:11
作者
GULLNER, HG
BARTTER, FC
机构
[1] Hypertension-Endocrine Branch National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda
关键词
D O I
10.1016/0024-3205(79)90454-5
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The effect of the hypothalamic undecapeptide substance P on renin secretion rate was studied in the denervated dog kidney. Intrarenal infusion of substance P at a rate of 0.2 ng/kg/min suppressed renin secretion rates from 258.5 ± 28.5 ng/min to 133.1 ± 23.2 ng/min (p<0.001). Substance P infused at this dose neither changed blood pressure nor did it affect renal cortical plasma flow, glomerular filtration rate or sodium excretion. Thus, the suppression of renin release by substance P cannot be explained by any of the known control mechanisms. It is proposed that substance P participates in the control of renin release by a direct effect on the juxtaglomerular cells. © 1979.
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页码:2449 / 2454
页数:6
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