EFFICACY AND SAFETY OF A DIAZEPAM AND MEPERIDINE COMBINATION FOR PEDIATRIC GASTROINTESTINAL PROCEDURES

被引:5
作者
NAHATA, MC
MURRAY, RD
ZINGARELLI, J
LI, BUK
MCCLUNG, HJ
LININGER, B
机构
[1] OHIO STATE UNIV,COLL MED,COLUMBUS,OH 43210
[2] CHILDRENS HOSP,DEPT PEDIAT,COLUMBUS,OH 43205
[3] CHILDRENS HOSP,DEPT NURSING,COLUMBUS,OH 43205
关键词
Diazepam; Gastrointestinal procedures; Meperidine; Sedation;
D O I
10.1097/00005176-199004000-00012
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Little has been published about outpatient sedation for pediatric patients. We designed a study to evaluate the efficacy and adverse effects of diazepam and meperidine in combination for sedation in ambulatory pediatric patients undergoing endoscopy, colonoscopy, or liver biopsy. Thirty patients (7 months-20 years) were observed. Each patient received a single combined dose of intravenous diazepam and meperidine. The standard dose was 0.1 mg/kg for diazepam and 2.0 mg/kg for meperidine. In patients weighing >100 lb, set doses of meperidine (100 mg) and diazepam (5 mg) were used. The time to achieve sedation and the vital signs were measured; cooperation, emotional state, and drowsiness were rated before, during, and after procedures. The amnesic effect was noted, as were any adverse effects. Diazepam and meperidine were effective in 26 of 30 patients, with sedation generally produced within 2-3 min. Cooperation and emotional state improved significantly following drug administration (p < 0.05). When a prospective 24-h telephone follow-up study was instituted in 40 consecutive patients receiving diazepam and meperidine no significant adverse effects were noted. Only 20% of patients old enough to be questioned remembered the procedure. Diazepam and meperidine in combination appear to be effective and safe in pediatric patients undergoing gastrointestinal procedures. Prolonged monitoring of patients does not appear necessary in this patient population. © 1990 Raven Press Ltd, New York.
引用
收藏
页码:335 / 338
页数:4
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