NEW CHROMOGENIC ASSAY FOR THE SPECIFIC DETERMINATION OF PROTHROMBIN

被引：8

作者：

FRANCIS, JL

机构：

[1] Department of Haematology, Chester City Hospital, Chester CH2 3EH, Hoole Lane

来源：

JOURNAL OF CLINICAL PATHOLOGY | 1979年 / 32卷 / 07期

关键词：

D O I：

10.1136/jcp.32.7.651

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

A new method for the specific assay of prothrombin is described which utilises Taipan snake venom and the chromogenic substrate Tos-Gly-Pro-Arg-pNA (Chromozym TH). The method is sensitive and reproducible and shows good correlation with a conventional specific assay for prothrombin. The reaction is dependent on calcium ions and phospholipid, and is therefore sensitive to the coumarin-induced prothrombin defect. The assay is rapid and well suited for use in the routine coagulation laboratory.

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页码：651 / 654

页数：4

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