SYNTHESIS OF PT-195M RADIOLABELED (-)-(R)-2-AMINOMETHYLPYRROLIDINE(1,1-CYCLOBUTANEDICARBOXYLATO)-2-PLATINUM(II) MONOHYDRATE USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：5

作者：

KAWAI, K

TAKADA, S

NAKANO, Y

EHRLICH, W

MAKI, H

AKABOSHI, M

机构：

[1] ROBERT KOCH INST,W-1000 BERLIN 65,GERMANY

[2] CHUGAI PHARMACEUT CO LTD,CTR DRUG METAB,TOSHIMA KU,TOKYO 171,JAPAN

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY-LETTERS | 1992年 / 164卷 / 02期

关键词：

D O I：

10.1007/BF02167972

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An experimental method is described for the synthesis of Pt-195m-radiolabeled (-)-(R)-2-aminomethylpyrrolidine (1,1-cyclobutanedicarboxylato)-2-platinum (II) (DWA2114R). An amount of 10 mg of 95% enriched Pt-194 was irradiated for 75 h in the hydraulic conveyer of the KUR at a thermal neutron flux of approximately 8.1 x 10(13) n.cm-2.sec-1 and the Pt-195m-radiolabeled DWA2114R was purified using HPLC. The chemical yield is higher than 65%, its chemical purity is greater than 99.2%, the radiochemical purity is nearly 100%, and the specific activity is 6.7 MBq. mg-1 DWA2114R.

引用

页码：123 / 130

页数：8

共 12 条

[1]

AKABOSHI M, 1987, Annual Reports of the Research Reactor Institute Kyoto University, V20, P150

[2] STRUCTURE AND ACTIVITY RELATIONSHIPS OF PLATINUM COMPLEXES WITH ANTI-TUMOUR ACTIVITY [J].