DECREASED PLATELET SEROTONIN LEVELS IN SYSTEMIC LUPUS-ERYTHEMATOSUS

被引：26

作者：

MEYERHOFF, J ^{[1
]}

DORSCH, CA ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV, SCH MED, DEPT MED, DIV RHEUMATOL, BALTIMORE, MD 21218 USA

来源：

ARTHRITIS AND RHEUMATISM | 1981年 / 24卷 / 12期

关键词：

D O I：

10.1002/art.1780241207

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Platelet serotonin levels were measured in 41 patients with systemic lupus erythematosis (SLE) and 36 normal controls. SLE patients had significantly lower mean serotonin levels (243 .+-. 131 vs. 414 .+-. 175 ng/109 platelets P < 0.001); the lowest levels occurred in those patients with active disease. No differences in mean platelet serotonin levels were found by comparing patients with or without a history of renal disease, thrombocytopenia or neuropsychiatric involvement. Decreased platelet seronin did not correlate with increased release of platelet granule constituents, as measured by plasma levels of the .alpha.-granule protein, .beta.-thromboglobulin.

引用

页码：1495 / 1500

页数：6

共 32 条

[1] COMPARISON OF SEROTONIN AND ATP CONTENT IN PLATELETS FROM SUBJECTS WITH DOWNS-SYNDROME [J].

BAYER, SM ;

MCCOY, EE .

BIOCHEMICAL MEDICINE, 1974, 9 (03) :225-232

[2]

BEURLINGHARBURY C, 1978, BLOOD, V52, P13

[3] INTRARENAL PLATELET CONSUMPTION IN DIFFUSE PROLIFERATIVE NEPHRITIS OF SYSTEMIC LUPUS-ERYTHEMATOSUS [J].

CLARK, WF ;

LEWIS, ML ;

CAMERON, JS ;

PARSONS, V .

CLINICAL SCIENCE AND MOLECULAR MEDICINE, 1975, 49 (03) :247-252

[4] INCREASED PERCENTAGE OF MEGATHROMBOCYTES IN VARIOUS CLINICAL DISORDERS [J].

GARG, SK ;

LACKNER, H ;

KARPATKI.S .

ANNALS OF INTERNAL MEDICINE, 1972, 77 (03) :361-+

[5] PLATELET STORAGE POOL DEFICIENCY AND PROSTAGLANDIN SYNTHESIS IN CHRONIC GRANULOCYTIC LEUKEMIA [J].

GERRARD, JM ;

STODDARD, SF ;

SHAPIRO, RS ;

COCCIA, PF ;

RAMSAY, NKC ;

NESBIT, ME ;

RAO, GHR ;

KRIVIT, W ;

WHITE, JG .

BRITISH JOURNAL OF HAEMATOLOGY, 1978, 40 (04) :597-607

[6] SERUM FACTORS RELEASING SEROTONIN FROM NORMAL PLATELETS - RELATION TO MANIFESTATIONS OF SYSTEMIC LUPUS-ERYTHEMATOSUS [J].

GINSBERG, MH ;

OMALLEY, M .

ANNALS OF INTERNAL MEDICINE, 1977, 87 (05) :564-567

[7]

HAMBERG M, 1974, LANCET, V2, P223

[8] ACTIVATION OF BLOOD-CLOTTING IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS - RELATIONSHIP TO DISEASE ACTIVITY [J].

HARDIN, JA ;

CRONLUND, M ;

HABER, E ;

BLOCH, KJ .

AMERICAN JOURNAL OF MEDICINE, 1978, 65 (03) :430-436

[9]

HIRSCHMAN RJ, 1973, BRIT J HAEMATOL, V24, P793, DOI 10.1111/j.1365-2141.1973.tb01707.x

[10] INHIBITION OF ARACHIDONIC-ACID RELEASE FROM CELLS AS BIOCHEMICAL-ACTION OF ANTI-INFLAMMATORY CORTICOSTEROIDS [J].

HONG, SL ;

LEVINE, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (05) :1730-1734

← 1 2 3 4 →