DETERMINATION OF SERUM CREATININE BY ISOTOPE-DILUTION MASS-SPECTROMETRY WITH LIQUID-CHROMATOGRAPHIC SEPARATION

被引：5

作者：

TAKATSU, A

NISHI, S

机构：

[1] National Chemical Laboratory for Industry, Ibaraki 305, Higashi, Tsukuba

来源：

ANALYTICAL SCIENCES | 1990年 / 6卷 / 03期

关键词：

electron impact ionization technique; high performance liquid chromatography; Isotope dilution mass spectrometry; serum creatinine;

D O I：

10.2116/analsci.6.347

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Isotope dilution mass spectrometry with liquid chromatography for the determination of serum creatinine is studied. After adding labeled (15N2) creatinine to the serum, creatinine was isolated using high performance liquid chromatography. Measurements were performed by electron impact mass spectrometry with use of a direct insertion device. Analytical results of the N1ST (formerly NBS) SRM serum showed satisfactory agreement with the certified value; the relative standard deviation of about 2% was obtained. © 1990, The Japan Society for Analytical Chemistry. All rights reserved.

引用

页码：347 / 350

页数：4

共 13 条

[1] HPLC ANALYSIS OF CREATININE IN HUMAN-PLASMA AND URINE [J].