4-TRIFLUOROMETHYLIMIDAZOLE AND 5-TRIFLUOROMETHYLIMIDAZOLE - NOVEL CYCLIZATION OF TRIFLUOROACETYLATED ALDEHYDE DIMETHYLHYDRAZONES

被引：20

作者：

KAMITORI, Y

HOJO, M

MASUDA, R

OHARA, S

KAWASAKI, K

KAWAMURA, Y

TANAKA, M

机构：

[1] Department of Industrial Chemistry, Faculty of Engineering, Kobe University, Kobe

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1990年 / 27卷 / 03期

关键词：

D O I：

10.1002/jhet.5570270303

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Thermally induced cyclization reaction of trifluoroacetylated arylaldehyde dimethylhydrazones 1 in refluxing toluene afforded 1‐methyl‐4‐aryl‐5‐trifluoromethylimidazoles 2 in good yields. In contrast thermal cyclization of 1 in the presence of silica gel gave regioisomeric 1‐methyl‐4‐trifluoromethyl‐5‐aryl‐imidazoles 5 as major products. These reactions could be extended to the syntheses of related several 1,4,5‐trisubstituted imidazoles. Copyright © 1990 Journal of Heterocyclic Chemistry

引用

页码：487 / 495

页数：9

共 7 条

[1] THE UNUSUAL CYCLIZATION OF BENZIL MONOHYDRAZONES TO 4,5-DIPHENYLIMIDAZOLES [J].