NON-A, NON-B HEPATITIS SPECIFIC ANTIBODIES DIRECTED AT HOST-DERIVED EPITOPE - IMPLICATION FOR AN AUTOIMMUNE PROCESS

被引:205
作者
MISHIRO, S
HOSHI, Y
TAKEDA, K
YOSHIKAWA, A
GOTANDA, T
TAKAHASHI, K
AKAHANE, Y
YOSHIZAWA, H
OKAMOTO, H
TSUDA, F
PETERSON, DA
MUCHMORE, E
机构
[1] JAPANESE RED CROSS, CTR BLOOD, SAITAMA, JAPAN
[2] YAMANASHI MED COLL, DEPT INTERNAL MED 1, YAMANASHI, JAPAN
[3] HIROSHIMA UNIV, SCH MED, DEPT HYG, HIROSHIMA 730, JAPAN
[4] JICHI MED SCH, DIV IMMUNOL, MINAMI KAWACHI, TOCHIGI 32904, JAPAN
[5] ABBOTT LABS, N CHICAGO, IL 60064 USA
[6] KITASATO INST, IMMUNOL SECT, TOKYO 108, JAPAN
[7] HAMAMATSU UNIV, SCH MED, DEPT PUBL HLTH, HAMAMATSU, SHIZUOKA 43131, JAPAN
[8] NYU MED CTR, EXPTL MED & SURG PRIMATES LAB, NEW YORK, NY 10016 USA
关键词
D O I
10.1016/0140-6736(90)93101-T
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A cDNA clone (GOR47-1) bearing an epitope with an aminoacid sequence GRRGQKAKSNPNRPL (GOR epitope) was isolated from the plasma of a laboratory chimpanzee infected with human non-A, non-B hepatitis (NANBH) agent. The epitope was not encoded by reported sequences of hepatitis C virus (HCV) but instead was coded for by a host cellular sequence. An enzyme-linked immunosorbent assay (ELISA) was developed for antibodies to the GOR epitope (anti-GOR). A patient with acute NANBH produced both IgM and IgG classes of anti-GOR in the acute phase of the illness, with concentrations of IgG class anti-GOR rising when anti-HCV became detectable. Anti-GOR was detected in serum from 59 (81%) of 73 patients with chronic NAN BH, 40 (65%) of 62 with NANB liver cirrhosis, and 25 (63%) of 40 NANB patients with primary hepatocellular carcinoma, but in only less than 10% of patients with chronic liver diseases due to hepatitis B virus, alcohol, or an autoimmune disorder, and in only 2% of voluntary blood donors. Circulating HCV-RNA was detected by polymerase chain reaction (PCR) in most patients seropositive for anti-GOR but negative for anti-HCV. Detection of anti-GOR would therefore help in the diagnosis of NANBH and in reducing the occurrence of post-transfusion hepatitis. © 1990.
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收藏
页码:1400 / 1403
页数:4
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