A DIRECT SULFHYDRYLATION PATHWAY IS USED FOR METHIONINE BIOSYNTHESIS IN PSEUDOMONAS-AERUGINOSA

被引：60

作者：

FOGLINO, M ^{[1
]}

BORNE, F ^{[1
]}

BALLY, M ^{[1
]}

BALL, G ^{[1
]}

PATTE, JC ^{[1
]}

机构：

[1] CNRS,CHIM BACTERIENNE LAB,F-13402 MARSEILLE 20,FRANCE

来源：

MICROBIOLOGY-UK | 1995年 / 141卷

关键词：

METHIONINE BIOSYNTHESIS; PSEUDOMONAS; SULFHYDRYLATION;

D O I：

10.1099/13500872-141-2-431

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The relationship between genes and enzymes in the methionine biosynthetic pathways has been studied in Pseudomonas aeruginosa. The first step is catalysed by an O-succinylhomoserine synthase,. the product of the metA gene mapped at 20 min on the chromosome. The second step is achieved by direct sulfhydrylation, involving the enzyme encoded by a metZ gene that we have identified and sequenced, located at 40 min. Thus Pseudomonas appears to be the only organism so far described that uses O-succinylhomoserine as substrate for a direct sulfhydrylation. As in yeast, the two transsulfuration pathways between cysteine and homocysteine, with cystathionine as an intermediate, probably exist in parallel in this organism.

引用

页码：431 / 439

页数：9