SYNTHESIS AND PROPERTIES OF 2,6-DIHYDROXYLAMINOPURINE AND ITS 9-BETA-D-RIBOFURANOSYL DERIVATIVE

被引：7

作者：

GINERSOROLLA, A

NANOS, C

BURCHENAL, JH

DOLLINGER, M

BENDICH, A

机构：

[1] Divisions of Biological Chemistry and Drug Resistance, Sloan-Kettering Institute for Cancer Research, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University Medical College, New York

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1968年 / 11卷 / 01期

关键词：

D O I：

10.1021/jm00307a600

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Syntheses of 2,6-dihydroxylaminopurine and its 9-β-p-ribofuranosyl derivative from the corresponding 6-chloro-2-fluoro compounds and hydroxylamine are described. The dihydmxylaminopurines were converted into the corresponding diamines by reduction with Raney nickel. Several mouse leukemias and Ridgeway osteogenic sarcoma were inhibited by 2,6-dihydroxylaminopurine, and the pattern of activity in various resistant lines of mouse leukemia suggested that this compound may exert its antileukemic effect by a mechanism similar to that of 6-mereaptopurine. © 1968, American Chemical Society. All rights reserved.

引用

页码：52 / +

页数：1

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