INHIBITION OF PROTEIN KINASE-C PREVENTS PHORBOL ESTER-INDUCED BUT NOT MUSCARINE-INDUCED DEPOLARIZATIONS IN THE RAT SUPERIOR CERVICAL-GANGLION

被引：13

作者：

GROVE, EA ^{[1
]}

CAULFIELD, MP ^{[1
]}

EVANS, FJ ^{[1
]}

机构：

[1] UNIV LONDON,SCH PHARM,LONDON,ENGLAND

来源：

NEUROSCIENCE LETTERS | 1990年 / 110卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

M-current; Muscarine; Muscarinic receptor; Phorbol ester; Protein kinase C; Staurosporine; Superior cervical ganglion;

D O I：

10.1016/0304-3940(90)90805-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The role of protein kinase C (PKC) activation in mediating muscarinic depolarization was assessed in the rat superior cervical ganglion. Staurosporine, an inhibitor of PKC, abolished a depolarization elicited by the direct PKC activator β-phorbol 12,13-dibutyrate, but had little effect on the response to muscarine. Thus, activation of PKC may not be an obligatory transduction step between muscarinic receptor stimulation and depolarization. © 1990.

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页码：162 / 166

页数：5

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