THE ROLE OF 5-HYDROXYTRYPTAMINE (5-HT) RECEPTOR SUBTYPES AND PLASTICITY IN THE 5-HT SYSTEMS IN THE REGULATION OF NOCICEPTIVE SENSITIVITY

被引：102

作者：

EIDE, PK

HOLE, K

机构：

[1] Department of Physiology, University of Bergen, Bergen

来源：

CEPHALALGIA | 1993年 / 13卷 / 02期

关键词：

5-HYDROXYTRYPTAMINE; NEURONAL PLASTICITY; NOCICEPTION; RECEPTOR SUBTYPES;

D O I：

10.1046/j.1468-2982.1993.1302075.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This review shows that the role of 5-hydroxytryptamine (5-HT) in the regulation of nociception depends on the 5-HT receptor subtypes involved and on long-term functional changes in the 5-HT receptors. Stimulation of the 5-HT1 receptors, as well as of the 5-HT2 and 5-HT3 receptors, may reduce nociceptive sensitivity. In addition, activation of 5-HT2 and 5-HT3 receptors may also enhance nociceptive sensitivity. Up- or down-regulation of the 5-HT receptors may result in long-lasting changes, plasticity, in the 5-HT systems. Lesioning of 5-HT neurons induces denervation supersensitivity to 5-HT, and prolonged stimulation of 5-HT receptors may produce subsensitivity to 5-HT. In the spinal cord denervation supersensitivity to 5-HT may depend on reduced release of substance P (SP). An increase in the release of SP, on the other hand, may reduce the effects of 5-HT receptor activation. Long-term treatment with antidepressants which are used in clinical pain therapy appears to up-regulate the 5-HT1 receptors and to down-regulate the 5-HT2 receptors.

引用

页码：75 / 85

页数：11

共 100 条

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