IMMUNOSTIMULANT AGENTS FROM ANDROGRAPHIS-PANICULATA

被引：286

作者：

PURI, A

SAXENA, R

SAXENA, RP

SAXENA, KC

SRIVASTAVA, V

TANDON, JS

机构：

[1] CENT DRUG RES INST,DIV MED CHEM,PB NO 173,CHATTAR MANZIL,LUCKNOW 226001,UTTAR PRADESH,INDIA

[2] CENT DRUG RES INST,DIV BIOCHEM,LUCKNOW 226001,UTTAR PRADESH,INDIA

来源：

JOURNAL OF NATURAL PRODUCTS | 1993年 / 56卷 / 07期

关键词：

D O I：

10.1021/np50097a002

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

EtOH extract and purified diterpene andrographolides of Andrographis paniculata (Acanthaceae) induced significant stimulation of antibody and delayed type hypersensitivity (DTH) response to sheep red blood cells (SRBC) in mice. The plant preparations also stimulated nonspecific immune response of the animals measured in terms of macrophage migration index (MMI) phagocytosis of C-14-leucine labelled Escherichia coli and proliferation of splenic lymphocytes. The stimulation of both antigen specific and nonspecific immune response was, however, of lower order with andrographolide than with the EtOH extract, suggesting thereby that substance(s) other than andrographolide present in the extract may also be contributing towards immunostimulation.

引用

页码：995 / 999

页数：5

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