SUSCEPTIBILITY OF FREQUENT URINARY PATHOGENS TO FOSFOMYCIN TROMETAMOL AND 8 OTHER ANTIBIOTICS - RESULTS OF AN ITALIAN MULTICENTER SURVEY

被引:14
作者
SCHITO, GC
CHEZZI, C
NICOLETTI, G
MOREDDU, M
ARCANGELETTI, MC
STEFANI, S
ALBINI, E
DELBONO, GP
机构
[1] UNIV CATANIA,IST MICROBIOL,I-95124 CATANIA,ITALY
[2] UNIV PARMA,IST MICROBIOL,I-43100 PARMA,ITALY
[3] ZAMBON RES SPA,DIV RIC & SVILUPPO,I-20091 BRESSO,ITALY
关键词
D O I
10.1007/BF01710017
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
In order to assess the resistance profile for fosfomycin trometamol after several years of clinical use in Italy, this study has explored the susceptibility to fosfomycin and eight other antibacterial drugs of 6,021 strains isolated from 23,816 urines during 1990 in three teaching hospitals located in Genoa, Parma and Catania. Gram-negative strains, notably Escherichia coli (41.6%), were primarily involved. Amoxicillin was the least active compound with resistance in 41.4% of the isolates. Fosfomycin showed the lowest rate of resistance in both gram-negative (2.8%) and gram-positive (2.1%) pathogens. This was followed by norfloxacin with a resistance rate of 11.8% and netilmicin with 12.2%. These results indicate that fosfomycin-trometamol may continue to be used in single-dose treatment of urinary tract infections even in the absence of , microbiological data since the prevalence of resistance to the drug is, at present, so low that therapeutic failure is highly improbable.
引用
收藏
页码:S291 / S295
页数:5
相关论文
共 8 条
[1]   BRIEF OVERVIEW OF SINGLE-DOSE THERAPY FOR UNCOMPLICATED URINARY-TRACT INFECTIONS [J].
BAILEY, RR .
CHEMOTHERAPY, 1990, 36 :27-30
[2]   INVITRO ACTIVITY OF LY146032 ALONE AND IN COMBINATION WITH OTHER ANTIBIOTICS AGAINST GRAM-POSITIVE BACTERIA [J].
DEBBIA, E ;
PESCE, A ;
SCHITO, GC .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (02) :279-281
[3]  
Lennette E.H., 1980, MANUAL CLIN MICROBIO, P195
[4]   FOSFOMYCIN TROMETAMOL-MANAGEMENT OF LOWER URINARY-TRACT INFECTIONS [J].
NEU, HC .
CHEMOTHERAPY, 1990, 36 :53-55
[5]  
NORRBY SR, 1990, REV INFECT DIS, V12, P458
[6]  
PESCE A, 1991, IN PRESS REV INFECT
[7]  
PEZZLO M, 1988, Clinical Microbiology Reviews, V1, P268
[8]  
PINASI C, 1987, EUR UROL, V13, P80