5-HT(3) RECEPTORS AUGMENT NEURONAL, CHOLINERGIC CONTRACTIONS IN GUINEA-PIG TRACHEA

被引：26

作者：

RIZZO, CA

KREUTNER, W

CHAPMAN, RW

机构：

[1] Schering-Plough Research Institute, Kenilworth, NJ

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 234卷 / 01期

关键词：

5-HT; (5-HYDROXYTRYPTAMINE; SEROTONIN); 5-HT(3) RECEPTORS; CHOLINERGIC AIRWAY CONSTRICTION;

D O I：

10.1016/0014-2999(93)90712-Q

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Serotonin (5-HT) and the selective 5-HT3 receptor agonist, 2-methyl-5-hydroxytryptamine enhanced electrical field stimulated contractions of the isolated guinea pig trachea. 5-HT (EC50 = 3.5 muM) was twice as potent as 2-methyl-5-hydroxytryptamine (EC50 = 7.4 muM). The effects of 5-HT and 2-methyl-5-hydroxytryptamine were antagonized by the selective 5-HT3 receptor antagonist, zacopride (apparent pA2 = 7.60 against 2-methyl-5-hydroxytryptamine). 2-Methyl-5-hydroxytryptamine (10 muM) had no effect on contractile responses to exogenous acetylcholine. Furthermore, the increase in electrical field stimulated contraction by 2-methyl-5-hydroxytryptamine was unchanged by hexamethonium (100 muM) but contractions were blocked by atropine (1 muM). These results suggest that excitatory 5-HT3 receptors exist on postganglionic cholinergic nerves in the isolated guinea pig trachea.

引用

页码：109 / 112

页数：4

共 15 条

[1] SEROTONIN INDUCED RELEASE OF ACETYLCHOLINE FROM NEURONS IN THE BRONCHIAL SMOOTH-MUSCLE OF THE RAT [J].