MECHANISM OF INHIBITORY-ACTION OF ETHANOL ON ENDOTHELIUM-DEPENDENT RELAXATION IN RAT AORTA

被引：15

作者：

HATAKE, K ^{[1
]}

WAKABAYASHI, I ^{[1
]}

HISHIDA, S ^{[1
]}

机构：

[1] HYOGO MED UNIV,DEPT HYG,NISHINOMIYA,HYOGO 663,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 238卷 / 2-3期

关键词：

ETHANOL; ACETYLCHOLINE; ENDOTHELIUM; VASORELAXATION; AORTA; (RAT);

D O I：

10.1016/0014-2999(93)90883-J

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Using isolated rat aortic strips, we investigated the inhibitory effect of ethanol on endothelium-dependent relaxation induced by acetylcholine, especially on that mediated by endothelium-derived relaxing factor. Ethanol depressed the relaxation induced by acetylcholine and inhibited the increase in the content of intravascular cyclic GMP induced by acetylcholine, but not that induced by sodium nitroprusside or calcimycin. Ethanol also inhibited the acetylcholine-induced relaxation resistant to nitro-L-arginine. These results suggest that ethanol can inhibit the cyclic GMP-dependent relaxation mediated by endothelium-derived relaxing factor. Furthermore, ethanol seems to depress the cyclic GMP-independent relaxation mechanism.

引用

页码：441 / 444

页数：4

共 12 条

[1] DIFFERENTIAL EFFECTS OF SUBSTRATE DEPLETION ON DRUG-INDUCED CONTRACTIONS OF RABBIT AORTA [J].