Molecular cloning of a mouse epithelial protein-tyrosine phosphatase with similarities to submembranous proteins

被引:45
作者
Hendriks, W [1 ]
Schepens, J [1 ]
Bachner, D [1 ]
Rijss, J [1 ]
Zeeuwen, P [1 ]
Zechner, U [1 ]
Hameister, H [1 ]
Wieringa, B [1 ]
机构
[1] UNIV ULM,DEPT CLIN GENET,D-89069 ULM,GERMANY
关键词
gene expression; mouse embryo; signal transduction; band; 4.1; discs; large homologous region; membrane skeleton; cytoskeleton;
D O I
10.1002/jcb.240590403
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Protein-tyrosine phosphatases (PTPases) form an important class of cell regulatory proteins. We have isolated overlapping cDNA clones that together comprise an 8 kb transcript encoding a novel murine PTPase which is expressed in various organs. Sequence analysis revealed an open reading frame of 2,460 amino acid residues. The predicted protein, PTP-BL, is a large non-transmembrane PTPase that exhibits 80% homology with PTP-BAS, a recently described human PTPase. PTP-BL shares some intriguing sequence homologies with submembranous proteins. It contains a band 4.1-like motif also present in the tumor suppressors neurofibromatosis 2 and expanded, five 80 amino acid repeats also present in the discs-large tumor suppressor, and a single catalytic phosphatase domain. No obvious homologies to other proteins were found for the N-terminal region of the protein other than human PTP-BAS. RNA in situ hybridization experiments show that the PTP-BL gene is expressed in epithelial cells, predominantly in kidney, lung, and skin. These data suggest a cell cortical localization for PTP-BL in epithelial cells and a possible role in the morphology and motility of epithelial tissues. (C) 1995 Wiley-Liss, Inc.
引用
收藏
页码:418 / 430
页数:13
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