EXPRESSION OF VASCULAR CELL-ADHESION MOLECULE-1 BY FOLLICULAR DENDRITIC CELLS

被引：8

作者：

HUANG, MJ ^{[1
]}

OSBORN, L ^{[1
]}

SVAHN, J ^{[1
]}

SCHIFFER, SB ^{[1
]}

ELISEO, L ^{[1
]}

ZHOU, LJ ^{[1
]}

RHYNHART, K ^{[1
]}

BENJAMIN, CD ^{[1
]}

FREEDMAN, AS ^{[1
]}

机构：

[1] HARVARD UNIV, SCH MED,DANA FARBER CANC INST,DEPT MED, DIV TUMOR IMMUNOL, BOSTON, MA 02115 USA

来源：

LEUKEMIA & LYMPHOMA | 1995年 / 18卷 / 3-4期

关键词：

D O I：

10.3109/10428199509059616

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Follicular dendritic cells are the major supporting cell of the germinal center microenvironment. The major function of follicular dendritic cells is to present antigen to B cells in secondary lymphoid tissues. Through cell-cell interactions, FDCs are hypothesized to be central to the regulation of normal B cell growth and differentiation. The major receptor-ligand pair which mediates B cell-FDC adhesion is the beta 1 integrin VLA-4, present on B cells and VCAM-1 expressed on FDCs. Follicular non-Hodgkin's lymphomas similarly employ this mechanism to bind to neoplastic germinal centers. The VCAM-1 molecule can exist as a 6 or 7 immunoglobulin domain form. The major form of VCAM-1 on activated endothelium is the 7 domain form. In this report we have determined by polymerase chain reaction of purified FDCs that they express predominantly mRNA for 7 domain VCAM-1. It is likely that the two forms of VCAM-1 are associated with distinct functions, therefore the expression of 7 domain VCAM-1 may be important in normal and neoplastic B celI-FDC interactions.

引用

页码：259 / 264

页数：6

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