Binding and catalysis with flexible locks and flexible keys

被引：7

作者：

Breslow, R

机构：

[1] Department of Chemistry, Columbia University

来源：

SUPRAMOLECULAR CHEMISTRY | 1995年 / 6卷 / 1-2期

关键词：

D O I：

10.1080/10610279508032518

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the final structure of an enzyme-substrate complex, or of a related molecular complex, the two components may fit together in a lock and key relationship, but flexibility is often needed in the binding process. Furthermore, flexibility is needed in enzyme-substrate complexes and their mimics to accommodate the geometric changes that the reaction causes. Examples of such situations from enzyme mimic studies are described.

引用

收藏

页码：41 / 47

页数：7

相关论文

共 27 条

[1] ON THE MECHANISM OF CATALYSIS BY RIBONUCLEASE - CLEAVAGE AND ISOMERIZATION OF THE DINUCLEOTIDE UPU CATALYZED BY IMIDAZOLE BUFFERS [J].

ANSLYN, E ;

BRESLOW, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (12) :4473-4482

[2] PROTON INVENTORY OF A BIFUNCTIONAL RIBONUCLEASE MODEL [J].

ANSLYN, E ;

BRESLOW, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (24) :8931-8932

[3] GEOMETRIC EVIDENCE ON THE RIBONUCLEASE MODEL MECHANISM [J].

ANSLYN, E ;

BRESLOW, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (15) :5972-5973

[4] VERY STRONG BINDING OF APPROPRIATE SUBSTRATES BY CYCLODEXTRIN DIMERS [J].

BRESLOW, R ;

GREENSPOON, N ;

GUO, T ;

ZARZYCKI, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (21) :8296-8297

[5] A NEGATIVE CATALYTIC TERM REQUIRES A COMMON INTERMEDIATE IN THE IMIDAZOLE BUFFER CATALYZED CLEAVAGE AND REARRANGEMENT OF RIBODINUCLEOTIDES [J].

BRESLOW, R ;

HUANG, DL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (26) :9621-9623

[6] RECOGNITION AND CATALYSIS IN NUCLEIC-ACID CHEMISTRY [J].

BRESLOW, R ;

XU, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (04) :1201-1207

[7] OPTIMIZATION OF METALLOCENE SUBSTRATES FOR BETA-CYCLODEXTRIN REACTIONS [J].

BRESLOW, R ;

TRAINOR, G ;

UENO, A .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, 105 (09) :2739-2744

[8] GEOMETRY OF ENOLIZATION USING A BIFUNCTIONAL CYCLODEXTRIN-BASED CATALYST [J].

BRESLOW, R ;

GRAFF, A .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (23) :10988-10989

[9] ADDITIONAL FLEXIBILITY SOLVES THE LEAVING GROUP-PROBLEM IN CYCLODEXTRIN ACYLATION [J].

BRESLOW, R ;

CHUNG, S .

TETRAHEDRON LETTERS, 1990, 31 (05) :631-634

[10] IMPROVED ACYLATION RATES WITHIN CYCLODEXTRIN COMPLEXES FROM FLEXIBLE CAPPING OF THE CYCLODEXTRIN AND FROM ADJUSTMENT OF THE SUBSTRATE GEOMETRY [J].

BRESLOW, R ;

CZARNIECKI, MF ;

EMERT, J ;

HAMAGUCHI, H .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (02) :762-770