CHEMICAL MODIFICATION OF TRYPTOPHAN RESIDUE IN COBRATOXIN

被引：58

作者：

CHANG, CC

HAYASHI, K

机构：

[1] Department of Biological Chemistry, Faculty of Pharmaceutical Sciences Kyoto University, Kyoto

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 37卷 / 05期

关键词：

D O I：

10.1016/0006-291X(69)90968-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The single tryptophan residue in cobratoxin has been converted into N′formyl-kynurenine by ozonization in formic acid, and also modified by reaction with 2-hydroxy-5-nitrobenzyl bromide. The data from amino acid analysis of modified derivatives show that these reactions are specific for tryptophan, and do not affect the other amino acids. The low toxicity of these modified products points to the importance of the intact tryptophan residue in cobratoxin for full activity. © 1969.

引用

页码：841 / &

共 16 条

[1]

BARMAN TE, 1967, J BIOL CHEM, V242, P5771

[2] THE SYNTHESIS OF N'-FORMYL-DL-KYNURENINE, NA-ACETYL-DL-KYNURENINE AND RELATED COMPOUNDS, AND OBSERVATIONS ON THE SYNTHESIS OF KYNURENINE [J].