EFFECT OF HYDROGEL LENS WEAR ON TEAR FILM STABILITY

被引：59

作者：

FABER, E

GOLDING, TR

LOWE, R

BRENNAN, NA

机构：

[1] Corneal Biophysics Laboratory, Department of Optometry, University of Melbourne, Parkville

来源：

OPTOMETRY AND VISION SCIENCE | 1991年 / 68卷 / 05期

关键词：

HYDROGEL CONTACT LENS; NONINVASIVE BREAKUP TIME (NIBUT); POSTLENS TEAR FILM; PRECORNEAL TEAR FILM; PRELENS TEAR FILM; WATER CONTENT;

D O I：

10.1097/00006324-199105000-00010

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Noninvasive break-up time (NIBUT) of the tears was measured in a controlled, randomized, double-masked study to assess: (1) the stability of the prelens tear film during wear of new high and low water content lenses and (2) the stability of the precorneal tear film following lens removal after 1 h of wear. The prelens tear film NIBUT of 6 subjects was found to be relatively constant over a 1-h wearing period, averaging 6.1 +/- 1.1 s (mean +/- SEM). These values were significantly (Scheffe's S test, p < 0.05) lower than those recorded for the precorneal tear film before lens insertion (33.5 +/- 10.6; mean +/- SEM), although 85% of prelens tear film NIBUT's were greater than the 3-s average interblink period reported previously for soft lens wearers. After lens removal, precorneal tear film NIBUT was reduced significantly compared to prewear levels (Scheffe's S test, p < 0.05) for up to 15 min. Application of the monomolecular growth model to the NIBUT recovery data revealed a half-time for recovery of 6.0 min, with recovery 95% complete 25.8 min after lens removal. Lens type was not a significant factor in tear film stability, either during wear or after lens removal. The basis for reduced precorneal tear film NIBUT after lens removal is unknown; however, a disruption of the mucin layer coating the corneal epithelium is the most likely mechanism. Indeed, the technique of measuring precorneal tear film NIBUT after lens removal may be a useful determinant of the extent to which contact lens wear disrupts the precorneal mucin layer, providing an indication of the susceptibility of the cornea to a variety of complications.

引用

页码：380 / 384

页数：5

共 25 条

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