INHIBITION OF GASTRIC-EMPTYING BY SODIUM OLEATE DEPENDS ON LENGTH OF INTESTINE EXPOSED TO NUTRIENT

被引:125
作者
LIN, HC
DOTY, JE
REEDY, TJ
MEYER, JH
机构
[1] CEDARS SINAI MED CTR, DEPT SURG, LOS ANGELES, CA 90048 USA
[2] VET ADM MED CTR, SEPULVEDA, CA 91343 USA
[3] UNIV CALIF LOS ANGELES, CTR ULCER RES & EDUC, LOS ANGELES, CA 90024 USA
[4] UNIV CALIF LOS ANGELES, SCH MED, LOS ANGELES, CA 90024 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1990年 / 259卷 / 06期
关键词
GASTROINTESTINAL MOTILITY; SMALL INTESTINE; FAT;
D O I
10.1152/ajpgi.1990.259.6.G1031
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Previously, we reported that inhibition of gastric emptying by glucose or acids depends on the length of gut exposed to the inhibitor ]Gastroenterology 95: A877, 1988; Am. J. Physiol. 256 (Gastrointest. Liver Physiol. 19): G404-G411, 1989]. In this study, we hypothesized that feedback control by fat may be similarly regulated. In dogs with chronic intestinal fistulas, we compared the intensity of intestinal feedback when different lengths of the small intestine were exposed to meals of 3, 9, or 27 mM sodium oleate. We found that 1) inhibition of liquid emptying was dose dependent, 2) intensity of negative feedback was dependent on both the concentration of the oleate and the length of gut exposed to fat, 3) full inhibitory effects was achieved with exposure of fat to 150 cm of gut, 4) inhibition from the distal one-half of gut was less potent than that generated from the proximal one-half of gut, and 5) on a molar basis oleate was 20 times as effective as glucose at inhibition of gastric emptying and that this difference was related to the slower rate of fat absorption.
引用
收藏
页码:G1031 / G1036
页数:6
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