GLY/LYS-CONTAINING PEPTIDE MACROCYCLES - SYNTHESIS AND CYCLIZATION STUDIES

被引：6

作者：

CRUSI, E ^{[1
]}

HUERTA, JM ^{[1
]}

ANDREU, D ^{[1
]}

GIRALT, E ^{[1
]}

机构：

[1] UNIV BARCELONA,DEPT ORGAN CHEM,MARTI FRANQUES 1-11,E-08028 BARCELONA,SPAIN

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 29期

关键词：

D O I：

10.1016/S0040-4039(00)97579-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Symmetric and lipophilic side-chain protected cyclic peptides have been prepared by solid-phase synthesis using an Fmoc-protocol on a TFA-sensitive resin to prepare the linear precursors, which have undergone cyclization with several in situ activating and coupling reagents. The cyclic peptides have been obtained in high yields and purity. © 1990.

引用

页码：4191 / 4194

页数：4

共 8 条

[1]

ALBERICIO F, 1985, INT J PEPT PROT RES, V26, P92

[2]

DEBER CM, 1979, 6TH PEPT P AM PEP S, P691

[3]

JI AX, 1983, INT J PEPT PROT RES, V22, P590

[4] COMPLEX-FORMATION WITH ALKALI AND ALKALINE-EARTH METAL-IONS OF CYCLIC OCTAPEPTIDES, CYCLO(PHE-PRO)4, CYCLO(LEU-PRO)4, AND CYCLO[LYS(Z)-PRO]4 [J].

KIMURA, S ;

IMANISHI, Y .

BIOPOLYMERS, 1983, 22 (11) :2383-2395

[5] SYNTHESIS OF CYCLIC PEPTIDES [J].

KOPPLE, KD .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1972, 61 (09) :1345-+

[6] CONFORMATIONAL STATES AND BIOLOGICAL-ACTIVITY OF CYCLIC PEPTIDES [J].

OVCHINNIKOV, YA ;

IVANOV, VT .

TETRAHEDRON, 1975, 31 (18) :2177-2209

[7]

OZEKI E, 1989, INT J PEPT PROT RES, V33, P14

[8]

TANIZAWA K, 1986, CHEM PHARM BULL, V34, P4081

← 1 →