METHIODIDE APPROACH TO THE SYNTHESIS OF 3-[2-(DIMETHYLAMINO)ETHYL]-5-[(1,1-DIOXO-5-METHYL-1,2,5-THIADIAZOLIDIN-2-YL)METHYL]-1H-INDOLE AND ANALOGS

被引：18

作者：

CASTRO, JL

MATASSA, VG

机构：

[1] Medicinal Chemistry Department, Merck Sharp md Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex CM20 2QR, Terlings Park, Eastwick Road

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 29期

关键词：

D O I：

10.1016/S0040-4039(00)60662-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tryptamines 1, 2 and 3 have been synthesised in a convergent and efficient manner by reaction of a novel methiodide 4c with the anions of the cyclic sulphamides 5, 6 and 7 as the key step.

引用

页码：4705 / 4708

页数：4

共 18 条

[1] ARYA VP, 1982, INDIAN J CHEM B, V21, P941
[2] NEW METHOD FOR METHYLATION OF AMINES
BORCH, RF
HASSID, AI
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1972, 37 (10) : 1673 - &
[3] BREWSTER JH, 1953, ORG REACTIONS, V7, P99
[4] CASTRO JL, 1993, IN PRESS CHEM LETT, V3
[5] DLDELIGANIS AV, 1991, HEADACHE, V31, P228
[6] THE DEVELOPMENT OF A HIGHLY SELECTIVE 5-HT(1) RECEPTOR AGONIST, SUMATRIPTAN, FOR THE TREATMENT OF MIGRAINE
FENIUK, W
HUMPHREY, PPA
[J]. DRUG DEVELOPMENT RESEARCH, 1992, 26 (03) : 235 - 240
[7] MITSUNOBU REACTIONS OF N-ALKYL AND N-ACYL SULFONAMIDES - AN EFFICIENT ROUTE TO PROTECTED AMINES
HENRY, JR
MARCIN, LR
MCINTOSH, MC
SCOLA, PM
HARRIS, GD
WEINREB, SM
[J]. TETRAHEDRON LETTERS, 1989, 30 (42) : 5709 - 5712
[8] IGOLEN J, 1969, CR ACAD SCI C CHIM, V269, P54
[9] Langer S. Z., 1992, SEROTONIN RECEPTOR S
[10] TRIMETHYLSILYL IODIDE AS A PEPTIDE DEBLOCKING AGENT
LOTT, RS
CHAUHAN, VS
STAMMER, CH
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1979, (11) : 495 - 496

← 1 2 →