Construction, expression and characterisation of a single chain anti-tumour antibody (scFv)-IL-2 fusion protein

被引：13

作者：

Boleti, E ^{[1
]}

Deonarain, MP ^{[1
]}

Spooner, RA ^{[1
]}

Smith, AJ ^{[1
]}

Epenetos, AA ^{[1
]}

George, AJT ^{[1
]}

机构：

[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,TUMOUR TARGETING LAB,IMPERIAL CANC RES FUND,ONCOL UNIT,LONDON W12 0NN,ENGLAND

来源：

ANNALS OF ONCOLOGY | 1995年 / 6卷 / 09期

关键词：

cytokines; fusion protein; interleukin-2; monoclonal antibodies; single-chain antibodies (scFv); targeted immunotherapy;

D O I：

10.1093/oxfordjournals.annonc.a059364

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We describe the production and preliminary characterisation of a fusion protein between interleukin-2 and a single-chain Fv version of the H17E2 anti-placental alkaline phosphatase (FLAP) antibody. This molecule could be used to target interleukin-2 to FLAP-expressing tumours.

引用

页码：945 / 947

页数：3

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