HEPATOCELLULAR-CARCINOMA IN CIRRHOTIC LIVERS - DETECTION WITH UNENHANCED AND IRON OXIDE-ENHANCED MR-IMAGING

被引：109

作者：

YAMAMOTO, H ^{[1
]}

YAMASHITA, Y ^{[1
]}

YOSHIMATSU, S ^{[1
]}

BABA, Y ^{[1
]}

HATANAKA, Y ^{[1
]}

MURAKAMI, R ^{[1
]}

NISHIHARU, T ^{[1
]}

TAKAHASHI, M ^{[1
]}

HIGASHIDA, Y ^{[1
]}

MORIBE, N ^{[1
]}

机构：

[1] KUMAMOTO UNIV,SCH MED,DEPT RADIOL TECHNOL,KUMAMOTO 860,JAPAN

来源：

RADIOLOGY | 1995年 / 195卷 / 01期

关键词：

IRON; LIVERNEOPLASMS; LIVER; MR; MAGNETIC RESONANCE (MR); CONTRAST ENHANCEMENT; RECEIVER OPERATING CHARACTERISTIC (ROC);

D O I：

10.1148/radiology.195.1.7892448

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

PURPOSE: To evaluate diagnostic accuracy with unenhanced and superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance (MR) imaging for detection of hepatocellular carcinoma (HCC) in cirrhotic livers. MATERIALS ANL) METHODS: Fifteen patients with 26 histologically proved HCCs associated with liver cirrhosis underwent imaging with T1-, T2-, and proton-density-weighted spin-echo (SE) and fast low-angle shot (FLASH) sequences. Lesion-to-liver contrast-to-noise ratios were measured in all sequences. Diagnostic performance of the imaging techniques was assessed by using receiver operating characteristic analysis. RESULTS: Enhanced SE and FLASH sequences were significantly more accurate (P <.005) for the detection of small HCCs. Among the unenhanced pulse sequences, the accuracy of tumor localization was highest with the T2-weighted SE sequences; however, 25% of the lesions were located incorrectly. Compared with unenhanced images, lesions were correctly located more often when SPIO-enhanced SE and FLASH sequences were used. CONCLUSION: SPIO-enhanced MR imaging with proton-density-weighted or FLASH sequences was more accurate in the detection of small HCCs in cirrhotic livers.

引用

页码：106 / 112

页数：7

共 20 条

[1] LIVER-TUMORS IN CIRRHOSIS - EXPERIMENTAL-STUDY WITH SPIO-ENHANCED MR IMAGING [J].

CLEMENT, O ;

FRIJA, G ;

CHAMBON, C ;

SCHOUMANCLAYES, E ;

MOSNIER, JF ;

POUPON, MF ;

BALKAU, B .

RADIOLOGY, 1991, 180 (01) :31-36

[2] DETECTION OF MALIGNANT-TUMORS IN END-STAGE CIRRHOTIC LIVERS - EFFICACY OF SONOGRAPHY AS A SCREENING TECHNIQUE [J].

DODD, GD ;

MILLER, WJ ;

BARON, RL ;

SKOLNICK, ML ;

CAMPBELL, WL .

AMERICAN JOURNAL OF ROENTGENOLOGY, 1992, 159 (04) :727-733

[3] DIAGNOSIS OF SMALL HEPATOCELLULAR-CARCINOMA - CORRELATION OF MR IMAGING AND TUMOR HISTOLOGIC-STUDIES [J].

EBARA, M ;

OHTO, M ;

WATANABE, Y ;

KIMURA, K ;

SAISHO, H ;

TSUCHIYA, Y ;

OKUDA, K ;

ARIMIZU, N ;

KONDO, F ;

IKEHIRA, H ;

FUKUDA, N ;

TATENO, Y .

RADIOLOGY, 1986, 159 (02) :371-377

[4] HEPATIC CIRRHOSIS AND HEPATITIS - MR IMAGING ENHANCED WITH SUPERPARAMAGNETIC IRON-OXIDE [J].

ELIZONDO, G ;

WEISSLEDER, R ;

STARK, DD ;

GUERRA, J ;

GARZA, J ;

FRETZ, CJ ;

TODD, LE ;

FERRUCCI, JT .

RADIOLOGY, 1990, 174 (03) :797-801

[5] SUPERPARAMAGNETIC IRON OXIDE-ENHANCED MR IMAGING - PULSE SEQUENCE OPTIMIZATION FOR DETECTION OF LIVER-CANCER [J].

FRETZ, CJ ;

ELIZONDO, G ;

WEISSLEDER, R ;

HAHN, PF ;

STARK, DD ;

FERRUCCI, JT .

RADIOLOGY, 1989, 172 (02) :393-397

[6] DETECTION OF HEPATIC METASTASES - COMPARISON OF CONTRAST-ENHANCED CT, UNENHANCED MR IMAGING, AND IRON-OXIDE ENHANCED MR IMAGING [J].

FRETZ, CJ ;

STARK, DD ;

METZ, CE ;

ELIZONDO, G ;

WEISSLEDER, R ;

SHEN, JH ;

WITTENBERG, J ;

SIMEONE, J ;

FERRUCCI, JT .

AMERICAN JOURNAL OF ROENTGENOLOGY, 1990, 155 (04) :763-770

[7] THE MEANING AND USE OF THE AREA UNDER A RECEIVER OPERATING CHARACTERISTIC (ROC) CURVE [J].

HANLEY, JA ;

MCNEIL, BJ .

RADIOLOGY, 1982, 143 (01) :29-36

[8]

HARATAKE J, 1990, CANCER, V65, P1985, DOI 10.1002/1097-0142(19900501)65:9<1985::AID-CNCR2820650918>3.0.CO

[9]

2-C

[10]

ICHIDA T, 1990, J SUBMICR CYTOL PATH, V22, P221

← 1 2 →