TOXICITY EVALUATION OF 2 TREATMENT REGIMENS FOR CYANIDE POISONING

被引：2

作者：

BHATTACHARYA, R

PANT, SC

KUMAR, D

DUBE, SN

机构：

[1] Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, Madhya Pradesh, 474002, Tansen Road

来源：

JOURNAL OF APPLIED TOXICOLOGY | 1995年 / 15卷 / 06期

关键词：

CYANIDE ANTIDOTE; METHEMOGLOBIN INDUCER; CLINICAL CHEMISTRY; PHYSIOLOGY; HISTOPATHOLOGY; RATS;

D O I：

10.1002/jat.2550150604

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Toxicological evaluation of two recently reported treatment protocols for cyanide-SN (sodium nitrite) + DMAP (4-dimethylaminophenol) and SN + HA (hydroxylamine)-was carried out in male rats. Both treatments produced transient hyperammonaemia and decreased mean arterial pressure. Heart rate decreased and respiratory rate increased, but these changes reached the level of significance only after SN + HA. Histopathological lesions in lung, liver (SN + HA) and kidney (SN + DMAP) were predominantly in the vicinity of blood vessels. The results indicate toxic effects in both treatment groups at a dose known to induce methaemoglobin concentration to the level of antidotal efficiency in cyanide intoxication.

引用

页码：439 / 441

页数：3

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