FREQUENCY OF TOXIC SHOCK SYNDROME TOXIN-PRODUCING AND ENTEROTOXIN-PRODUCING CLINICAL ISOLATES OF STAPHYLOCOCCUS-AUREUS

被引：25

作者：

LEHN, N

SCHALLER, E

WAGNER, H

KRONKE, M

机构：

[1] Institute for Medical Microbiology, Technical University Munich, Munich, 81675

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 1995年 / 14卷 / 01期

关键词：

D O I：

10.1007/BF02112617

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In 183 clinical isolates of Staphylococcus aureus, toxic shock syndrome toxin was detected in 13.7 %, enterotoxin A in 20.2 %, enterotoxin B in 7.7 %, enterotoxin C in 5.5 % and enterotoxin D in 3.3 %. Seventy-three (39.9 %) of the strains were found to produce one or more toxins. Multiple secretion of toxins was rare (< 1% of all strains) except for the combinations enterotoxin A with toxic shock syndrome toxin and enterotoxin A with enterotoxin D. These combinations were observed at Significantly higher frequencies (4.9 % and 2.2 %, respectively) than would have been expected from values calculated from respective individual frequencies (0.88% and 0.06%) (p < 0.0001). In comparison with Staphylococcus aureus strains isolated from miscellaneous material. Staphylococcus aureus blood culture isolates produced enterotoxin D in significantly larger amounts and at higher frequencies (p = 0.01 in both cases). These toxins might play an important pathogenic role in Staphylococcus aureus infections.

引用

页码：43 / 46

页数：4

共 21 条

[1]

Lautenschlager S., Herzog C., Zimmerli W., Course and outcome of bacteremia due to Staphylococcus aureus: evaluation of different clinical case definitions, Clinical Infectious Diseases, 16, pp. 567-573, (1993)

[2]

Todd J., Fishaut M., Kapral F., Welch T., Toxic shock syndrome associated with phage group-1 staphylococci, Lancet, 2, pp. 1116-1118, (1978)

[3]

Musser J.M., Schlievert P.M., Chow A.W., Ewan P., Kreiswirth B.N., Rosdahl V.T., Naidu A.S., Witte W., Selander R.K., A single clone of Staphylococcus aureus causes the majority of cases of toxic shock syndrome, Proceedings of the National Academy of Sciences of the USA, 87, pp. 225-229, (1990)

[4]

Bergdoll, Crass B.A., Reiser R.F., Robbins R.N., Lee A.C.M., Chesney P.J., Davis J.P., Vereront J.M., Wand P.J., A new staphylococcal enterotoxin, enterotoxin F, associated with toxic shock syndrome Staphylococcus aureus isolates, Lancet, 1, pp. 1017-1021, (1981)

[5]

Garbe P.L., Arko R.J., Reingold A.L., Staphylococcus aureus isolates from patients with nonmenstrual toxic shock syndrome, Journal of the American Medical Association, 253, pp. 2538-2542, (1985)

[6]

Kreiswirth B.N., Lofdahl S., Betley M.J., O'Reilly M., Schlievert P.M., Bergdoll, Novick R.P., The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophage, Nature, 305, pp. 709-712, (1983)

[7]

Dohlsten M., Hedlund G., Kalland T., Staphylococcal-enterotoxin-dependent cell mediated cytotoxicity, Immunology Today, 12, pp. 147-150, (1991)

[8]

Fischer H., Dohlsten M., Andersson U., Hedlund G., Ericsson P., Hansson J., Sjogren H.O., Production of TNF-alpha and TNF-beta by staphylococcal enterotoxin A activated human T cells, Journal of Immunology, 144, pp. 4663-4669, (1990)

[9]

Wieneke A.A., Comparison of four kits for the detection of staphylococcal enterotoxin in foods from outbreaks of food poisoning, International Journal of Food Microbiology, 14, pp. 305-312, (1991)

[10]

Weckbach L.S., Staneck J.L., Thompson, Bonventre P.F., Immunoblots for detection of toxic shock syndrome toxin 1 produced by Staphylococcus aureus, Journal of Clinical Microbiology, 28, pp. 1488-1490, (1990)

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