HUMAN STRIATAL CHOLINERGIC NEURONS IN DEVELOPMENT, AGING AND ALZHEIMERS-DISEASE

被引：18

作者：

GEULA, C

TOKUNO, H

HERSH, L

MESULAM, MM

机构：

[1] UNIV TEXAS,HLTH SCI CTR,DALLAS,TX 75235

[2] HARVARD UNIV,SCH MED,DEPT NEUROL,DIV NEUROSCI & BEHAV NEUROL,BULLARD & DENNY BROWN LABS,BOSTON,MA 02115

来源：

BRAIN RESEARCH | 1990年 / 508卷 / 02期

关键词：

Aging; Alzheimer's disease; Cholinergic neuron; Development; Neuronal size; Striatum;

D O I：

10.1016/0006-8993(90)90414-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The cross-sectional area of cholinergic neurons stained immunohistochemically for choline acetyltransferase were measured in the striatum of infants, young adults, aged individuals and patients with Alzheimer's disease. Cholinergic neurons were distributed throughout the caudate nucleus and the putamen and displayed no significant variations in size across the two structures. The cross-sectional area of striatal cholinergic neurons was smaller in infants as compared with all the other groups examined. No significant changes were observed in the size of these neurons as a consequence of aging or Alzheimer's disease. © 1990.

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页码：310 / 312

页数：3

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