AMINO-ACID CHANGES LINKED TO PYRIMETHAMINE RESISTANCE IN THE DIHYDROFOLATE-REDUCTASE THYMIDYLATE SYNTHASE GENE OF PLASMODIUM-FALCIPARUM

被引：445

作者：

COWMAN, AF ^{[1
]}

MORRY, MJ ^{[1
]}

BIGGS, BA ^{[1
]}

CROSS, GAM ^{[1
]}

FOOTE, SJ ^{[1
]}

机构：

[1] ROCKEFELLER UNIV,MOLEC PARASITOL LAB,NEW YORK,NY 10021

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1988年 / 85卷 / 23期

关键词：

D O I：

10.1073/pnas.85.23.9109

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：9109 / 9113

页数：5

共 33 条

[1] CHARACTERIZATION OF AN S-ANTIGEN SYNTHESIZED BY SEVERAL ISOLATES OF PLASMODIUM-FALCIPARUM [J].

ANDERS, RF ;

BROWN, GV ;

EDWARDS, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (21) :6652-6656

[2] PLASMODIUM-FALCIPARUM - INDUCTION, SELECTION, AND CHARACTERIZATION OF PYRIMETHAMINE-RESISTANT MUTANTS [J].

BANYAL, HS ;

INSELBURG, J .

EXPERIMENTAL PARASITOLOGY, 1986, 62 (01) :61-70

[3] UNSTABLE DNA AMPLIFICATIONS IN METHOTREXATE-RESISTANT LEISHMANIA CONSIST OF EXTRACHROMOSOMAL CIRCLES WHICH RELOCALIZE DURING STABILIZATION [J].

BEVERLEY, SM ;

CODERRE, JA ;

SANTI, DV ;

SCHIMKE, RT .

CELL, 1984, 38 (02) :431-439

[4] PRIMARY STRUCTURE OF THE GENE ENCODING THE BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE OF LEISHMANIA-MAJOR [J].

BEVERLEY, SM ;

ELLENBERGER, TE ;

CORDINGLEY, JS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (08) :2584-2588

[5] PLASMODIUM-FALCIPARUM - RAPID QUANTIFICATION OF PARASITEMIA IN FIXED MALARIA CULTURES BY FLOW-CYTOMETRY [J].

BIANCO, AE ;

BATTYE, FL ;

BROWN, GV .

EXPERIMENTAL PARASITOLOGY, 1986, 62 (02) :275-282

[6]

Blakley R. L., 1984, FOLATES PTERINES, P191

[7] MOLECULAR-CLONING AND SEQUENCE-ANALYSIS OF THE PLASMODIUM-FALCIPARUM DIHYDROFOLATE-REDUCTASE THYMIDYLATE SYNTHASE GENE [J].

BZIK, DJ ;

LI, WB ;

HORII, T ;

INSELBURG, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (23) :8360-8364

[8]

CHEN GX, 1987, MOL PHARMACOL, V31, P430

[9] SEPARATION OF LARGE DNA-MOLECULES BY CONTOUR-CLAMPED HOMOGENEOUS ELECTRIC-FIELDS [J].

CHU, G ;

VOLLRATH, D ;

DAVIS, RW .

SCIENCE, 1986, 234 (4783) :1582-1585

[10] OVERPRODUCTION OF A BIFUNCTIONAL THYMIDYLATE SYNTHETASE-DIHYDROFOLATE REDUCTASE AND DNA AMPLIFICATION IN METHOTREXATE-RESISTANT LEISHMANIA-TROPICA [J].

CODERRE, JA ;

BEVERLEY, SM ;

SCHIMKE, RT ;

SANTI, DV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (08) :2132-2136

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