ENCAPSULATED HEPATOCYTES FOR CONTROLLING HYPERBILIRUBINEMIA IN GUNN-RATS

被引：25

作者：

BRUNI, S ^{[1
]}

CHANG, TMS ^{[1
]}

机构：

[1] MCGILL UNIV,FAC MED,ARTIFICIAL CELLS & ORGANS RES CTR,MONTREAL H3A 2T5,QUEBEC,CANADA

来源：

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS | 1991年 / 14卷 / 04期

关键词：

BILIRUBIN; ARTIFICIAL CELLS; ENCAPSULATED; HEPATOCYTES;

D O I：

10.1177/039139889101400407

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Hepatocytes encapsulated in an alginate-polylysine-membrane were used to lower bilirubin levels in hyperbilirubinemia. The animal model was the Gunn rat. The microencapsulated hepatocytes were implanted intraperitoneally. 15x16(6) microencapsulated hepatocytes from Wistar rats lowered the bilirubin from 14 mg/100 ml to 6 mg/100 ml after 20 days. 15x10(6) microencapsulated hepatocytes from Sprague-Dawley rats lowered the bilirubin levels from 8 mg/100 ml to 5 mg/100 ml. They were as effective as free Sprague-Dawley hepatocytes. 12x10(6) Guinea pig hepatocytes, whether encapsulated or free, lowered the bilirubin from 9.36 mg/100ml to 4.37 mg/100 ml.

引用

页码：239 / 241

页数：3

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