5-ALPHA-PREGNAN-3-ALPHA-OL-20-ONE BLOCKS NICOTINE-INDUCED SEIZURES AND ENHANCES PAIRED-PULSE INHIBITION

被引：24

作者：

LUNTZLEYBMAN, V

FREUND, RK

COLLINS, AC

机构：

[1] UNIV COLORADO,INST BEHAV GENET,BOULDER,CO 80309

[2] UNIV COLORADO,SCH PHARM,BOULDER,CO 80309

[3] UNIV COLORADO,DEPT PSYCHOL,BOULDER,CO 80309

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 185卷 / 2-3期

关键词：

(Seizure); GABA (γ-aminobutyric acid); Hippocampus; Nicotine; Paired pulses; Progesterone metabolites;

D O I：

10.1016/0014-2999(90)90648-P

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

5α-Pregnan-3α-ol-20-one (3α-OH-DHP) blocked seizures induced by nicotine (4 mg/kg, i.p.) in C3H male mice with a ID50 of 2.37 ± 0.66 mg/kg (average ± 95% confidence limit). This steroid (1 μM) also increased paired-pulse inhibition in the hippocampus approximately 40% after 50 min exposure; nicotine (200 μM) partially reversed this effect. Since nicotine and 3α-OH-DHP may have opposite effects on endogenous inhibitory systems, it is proposed that nicotine-induced seizures may involve a disinhibitory mechanism and that 3α-OH-DHP protects against seizures by preventing disinhibition. © 1990.

引用

页码：239 / 242

页数：4

共 10 条

[1] ANTICONVULSANT PROFILE OF THE PROGESTERONE METABOLITE 5-ALPHA-PREGNAN-3-ALPHA-OL-20-ONE [J].