THE INTERNATIONAL TOXICITY EQUIVALENCY FACTOR (I-TEF) METHOD OF RISK ASSESSMENT FOR COMPLEX-MIXTURES OF DIOXINS AND RELATED-COMPOUNDS

被引:150
作者
KUTZ, FW
BARNES, DG
BOTTIMORE, DP
GREIM, H
BRETTHAUER, EW
机构
[1] VERSAR INC,SPRINGFIELD,VA 22151
[2] GESELL STRAHLEN & UMWELTFORSCH MBH,W-8042 NEUHERBERG,GERMANY
关键词
D O I
10.1016/0045-6535(90)90178-V
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The International Toxicity Equivalency Factor (I-TEF) method of risk assessment is an updated interim procedure for estimating the risks associated with exposures to complex mixtures of chlorinated dibenzo-p-dioxins and dibenzofurans (CDDs and CDFs). The I-TEF approach facilitates risk communication internationally by reducing large volumes of analytical data into a single number-International Toxicity Equivalents (I-TEQ). The I-TEF method has been officially adopted in Canada, the Netherlands, the Nordic countries, the United Kingdom, and the United States. As a result, the I-TEF method represents an improvement in an already useful risk assessment/regulatory tool. © 1990.
引用
收藏
页码:751 / 757
页数:7
相关论文
共 19 条
  • [1] POLYCHLORINATED DIBENZOFURANS (PCDFS) - EFFECTS OF STRUCTURE ON BINDING TO THE 2,3,7,8-TCDD CYTOSOLIC RECEPTOR PROTEIN, AHH INDUCTION AND TOXICITY
    BANDIERA, S
    SAWYER, T
    ROMKES, M
    ZMUDZKA, B
    SAFE, L
    MASON, G
    KEYS, B
    SAFE, S
    [J]. TOXICOLOGY, 1984, 32 (02) : 131 - 144
  • [2] TERATOGENIC EFFECTS OF POLYCHLORINATED DIBENZOFURANS IN COMBINATION IN C57BL/6N MICE
    BIRNBAUM, LS
    HARRIS, MW
    CRAWFORD, DD
    MORRISSEY, RE
    [J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 1987, 91 (02) : 246 - 255
  • [3] BOTTIMORE DP, 1989, IN PRESS J TOXICOL E
  • [4] COMMONER B, 1984, ENV EC ANAL ALTERNAT, V1
  • [5] DIOXIN-LIKE EFFECTS OBSERVED IN MALE-RATS FOLLOWING EXPOSURE TO OCTACHLORODIBENZO-PARA-DIOXIN (OCDD) DURING A 13-WEEK STUDY
    COUTURE, LA
    ELWELL, MR
    BIRNBAUM, LS
    [J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 1988, 93 (01) : 31 - 46
  • [6] CALCULATION OF 2,3,7,8-TCDD EQUIVALENT CONCENTRATIONS OF COMPLEX ENVIRONMENTAL CONTAMINANT MIXTURES
    EADON, G
    KAMINSKY, L
    SILKWORTH, J
    ALDOUS, K
    HILKER, D
    OKEEFE, P
    SMITH, R
    GIERTHY, J
    HAWLEY, J
    KIM, N
    DECAPRIO, A
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 1986, 70 : 221 - 227
  • [7] GRANT DL, 1977, 12TH P ANN WORKSH PE, P251
  • [8] UPTAKE AND DEPURATION STUDIES OF PCDDS AND PCDFS IN FRESH-WATER FISH
    KUEHL, DW
    COOK, PM
    BATTERMAN, AR
    [J]. CHEMOSPHERE, 1986, 15 (9-12) : 2023 - 2026
  • [9] KUTZ FW, 1988, CHEMOSPHERE, V17, P1
  • [10] REEXAMINATION OF DATA USED FOR ESTABLISHING TOXICITY EQUIVALENCE FACTORS (TEFS) FOR CHLORINATED DIBENZO-PARA-DIOXINS AND DIBENZOFURANS (CDDS AND CDFS)
    OLSON, JR
    BELLIN, JS
    BARNES, DG
    [J]. CHEMOSPHERE, 1989, 18 (1-6) : 371 - 381