INCREASED PROXIMAL TUBULAR REABSORPTION OF SODIUM IN CHILDHOOD DIABETES-MELLITUS

被引：24

作者：

OHAGAN, M

HOWEY, J

GREENE, SA

机构：

[1] Departments of Child Health and Biochemical Medicine, Ninewells Hospital and Medical School, Dundee

来源：

DIABETIC MEDICINE | 1991年 / 8卷 / 01期

关键词：

DIABETES; PROXIMAL TUBULE; SODIUM REABSORPTION; LITHIUM CLEARANCE; CHILDREN;

D O I：

10.1111/j.1464-5491.1991.tb01515.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 1 diabetes mellitus is associated with an increase in total exchangeable body sodium. To delineate a site of possible altered sodium handling, proximal tubular sodium reabsorption (PTR(Na) was measured in 30 diabetic children, age 12.0 (range 7-16) yr, duration of diabetes 4.5 (range 0.2-12) yr, and compared with 10 non-diabetic children, age 10.0 (range 8.6-12.5) yr. PTR(Na) was calculated from the fractional clearance of lithium, which was determined from a single blood sample and a random untimed urine sample, taken between 0700 and 0830 h at home, fasting, before insulin therapy. PTR(Na) was significantly increased in the diabetic children compared with the non-diabetic children (81.6(SE 1.0) vs 74.2(2.6) %, p = 0.014). There was no relationship of PTR(Na) with age, duration of diabetes, metabolic control (glycosylated haemoglobin, plasma and urinary glucose, plasma lactate), or urinary protein excretion (albumin, N-acetyl-beta-D-glucosaminidase). Elevated sodium reabsorption in the proximal renal tubule may account for the high total exchangeable body sodium found in Type 1 diabetic patients.

引用

页码：44 / 48

页数：5

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