INTERLEUKIN-6-INDUCED DIFFERENTIATION OF A HUMAN B-CELL LINE INTO IGM-SECRETING PLASMA-CELLS IS MEDIATED BY C-FOS

被引：24

作者：

KORHOLZ, D ^{[1
]}

GERDAU, S ^{[1
]}

ENCZMANN, J ^{[1
]}

ZESSACK, N ^{[1
]}

BURDACH, S ^{[1
]}

机构：

[1] UNIV DUSSELDORF,MED CTR,INST BLOOD COAGULAT & TRANSFUS MED,IMMUNOL LAB,W-4000 DUSSELDORF 1,GERMANY

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1992年 / 22卷 / 02期

关键词：

D O I：

10.1002/eji.1830220248

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of the protooncogene c-fos in interleukin (IL) 6-induced B cell differentiation was assessed. Treatment of SKW 6.4 cells with IL 6 induced a transient and early stimulation of c-fos sense mRNA expression. The effect appeared within 30 min and returned to basal levels after 2 h. The addition of antisense oligonucleotides to c-fos significantly inhibited IL 6-induced IgM production by SKW 6.4 cells (p < 0.001), whereas control oligonucleotides had no inhibitory effect. These results indicate that activation of c-fos is involved in IL 6-induced differentiation of SKW 6.4 cells into IgM-secreting cells.

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页码：607 / 610

页数：4

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