N-SUBSTITUTED PYRROLIDIN-3-ONES AS HETEROCYCLIC BUILDING-BLOCKS - ENANTIOSELECTIVE SYNTHESIS OF 8-EPI-CASTANOSPERMINE AND 1,8,8A-TRIEPI-CASTANOSPERMINE

被引：31

作者：

GALLAGHER, T ^{[1
]}

GILES, M ^{[1
]}

SUBRAMANIAN, RS ^{[1
]}

HADLEY, MS ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,HARLOW CM19 5AD,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 02期

关键词：

D O I：

10.1039/c39920000166

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Regioselective aldol reaction of dianion 1 with aldehyde 5 provides the basis of a new approach to the construction of polyhydroxy indolizidines and the application of this methodology to the synthesis of 8-epicastanospermine 11 and 1,8,8a-triepicastanospermine 12 is described.

引用

页码：166 / 168

页数：3

共 28 条

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